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| Product | Description | |
|---|---|---|
| Ridaforolimus | Ridaforolimus is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway. Synonyms: AP23573; AP 23573; AP-23573; MK8669; MK 8669; MK-8669; Deforolimus. Grades: >95% by HPLC. CAS No. 572924-54-0. Molecular formula: C53H84NO14P. Mole weight: 990.20. |  |
| Ridaforolimus | Ridaforolimus (MK-8669) is a potent and selective mTOR inhibitor; inhibits ribosomal protein S6 phosphorylation with an IC 50 of 0.2 nM in HT-1080 cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-8669; Deforolimus; AP23573. CAS No. 572924-54-0. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-50908. |  |
| Ridaforolimus | Ridaforolimus (the name has been changed from "deforolimus") is an immunosuppressant and a novel small-molecule inhibitor of the protein mammalian target of rapamycin (mTOR). Ridaforolimus inhibits cancer cell growth, cell division, metabolism, and angiogenesis by blocking mTOR. Group: Biochemicals. Alternative Names: 42- (Dimethylphosphinate) rapamycin; 9CI; AP 23573; Deforolimus; MK-8669; (1R, 2R, 4S)-4-[(2R)-2-[(1R, 9S, 12S, 15R, 16E, 18R, 19R, 21R, 23S, 24E, 26E, 28Z, 30S, 32S, 35R)-1, 18-dihydroxy-19, 30-dimethoxy-15, 17, 21, 23, 29, 35-hexamethyl-2, 3, 10, 14, 20-pentaoxo-11, 36-dioxa-4-azatricyclo[30.3.1.04, 9]hexatriaconta-16, 24, 26, 28-tetraen-12-yl]propyl]-2-methoxycyclohexyl dimethylphosphinate. Grades: Highly Purified. CAS No. 572924-54-0. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C??H??NO??P, Molecular Weight: 990.21. US Biological Life Sciences. |  Worldwide |
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