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| Product | Description | |
|---|---|---|
| Rigosertib | Rigosertib, a synthetic benzyl styryl sulfone, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM). Uses: A non-atp-competitive inhibitor of plk1. Synonyms: UNII-67DOW7F9GL; 2- [2-methoxy-5- [ [ (E) -2- (2, 4, 6-trimethoxyphenyl) ethenyl] sulfonylmethyl] anilino] acetic acid;ON-01910; ON 01910; ON01910. Grades: ≥95%. CAS No. 592542-59-1. Molecular formula: C21H25NO8S. Mole weight: 451.49. |  |
| Rigosertib | Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle [1] [2]. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC 50 of 9 nM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ON-01910. CAS No. 592542-59-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12037A. |  |
| Rigosertib sodium | Rigosertib (ON-01910 sodium salt), a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Synonyms: Glycine, N-[2-methoxy-5-[[[ (1E) -2- (2, 4, 6-trimethoxyphenyl) ethenyl]sulfonyl]methyl]phenyl]-, monosodium salt (9CI); (E)-2,4,6-Trimethoxystyryl 3-[(carboxymethyl)amino]-4-methoxybenzyl sulfone sodium salt; Novonex; ON 01910 sodium; ON01910 sodium; ON-01910 sodium; ON 01910 sodium salt; Rigosertib sodium. CAS No. 1225497-78-8. Molecular formula: C21H24NNaO8S. Mole weight: 473.47. | |
| Rigosertib sodium | Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle [1] [2]. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC 50 of 9 nM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ON-01910 sodium. CAS No. 592542-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12037. | |
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