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| Product | Description | |
|---|---|---|
| RKI-1447 | RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC 50 values of 14.5 nM and 6.2 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1342278-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15755. |  |
| RKI-1447 dihydrochloride | RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC 50 s of 14.5 and 6.2 nM for ROCK1 and ROCK2 , respectively [1]. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1782109-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110339. | |
| Rho Kinase Inhibitor XIII, RKI-1447 (1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Mesylate, 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea, Methanesulfonate, ROCK Inhibitor XIII) | A cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting, Rho Kinase inhibitor (IC50 = 14.5 and 6.2nM against ROCK1 and ROCK2, respectively), displaying much reduced potency against PKA, PKN1/PRK1, p70S6K/RPS6kB1, AKT1, MRCKa/CDC42BPA (85.5%, 80.5%, 61.9%, 56%, and 50.4% inhibition, respectively, by 1uM RKI-1447) or 15 other kinases. Selectively inhibits ROCK-dependent, but not mTORC2-dependent, cellular phosphorylations (effective conc. 0.1-1uM in MDA-MB-231, MDA-MB-468, and H1299 cultures). Shown to be efficacious in suppressing established tumor expansion in a murine ErbB2 mammary cancer model (200mg/kg/day i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S; CH?SO?H. US Biological Life Sciences. |  Worldwide |
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