Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| RN 1 dihydrochloride | RN 1 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| RN 1 dihydrochloride | RN 1 is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM), which exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50= 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). It blocks long-term but not short-term memory in mice following intraperitoneal administration. RN-1 also induces cytotoxicity in ovarian cancer cell lines and induces fetal hemoglobin synthesis while reducing disease pathology in sickle cell mice. Synonyms: RN 1 dihydrochloride; RN-1 dihydrochloride; RN1 dihydrochloride; 1- (4-methyl-1-piperazinyl) -2-[[ (1R*, 2S*) -2-[4-phenylmethoxy) phenyl]cyclopropyl]amino]ethanone dihydrochloride; RN-1, monohydrochloride; RN-1 2HCl. Grades: ≥97% by HPLC. CAS No. 1781835-13-9. Molecular formula: C23H29N3O2.2HCl. Mole weight: 452.42. |  |
| RN-1 dihydrochloride | RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC 50 of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC 50 values of 0.51 μM and 2.785 μM respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1781835-13-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110130. |  |
| Manidipine dihydrochloride | Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist ( IC 50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CV-4093. CAS No. 89226-75-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-17403. | |
| Pentamidine dihydrochloride | Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. It is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinII), a severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma brucei gambiense (West African Trypanosomiasis). Synonyms: Pentamidine dihydrochloride; Pentamidine-d4 2HCl; Pentamidine (dihydrochloride); Pentamidine HCl; Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-, dihydrochloride (9CI); PENTAMIDINE 2HCL; Pentamidinedihydrochloride; MP601205 dihydrochloride; CHEMBL543544; SCHEMBL7060561; HY-B0537A; DTXSID20964635; EX-A1489; 4-[5- (4-carbamimidoylphenoxy) pentoxy]benzenecarboximidamide; dihydrochloride; SW196985-3; A923917; 4,4'-(pentane-1,5-diylbis(oxy))dibenzimidamide 2HCl; Q27280201; 4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide dihydrochloride; 4,4'-[Pentane-1,5-diylbis(oxy)]di(benzene-1-carboximidamide)--hydrogen chloride (1/2). Grades: >98%. CAS No. 50357-45-4. Molecular formula: C19H24N4O2.2HCl. Mole weight: 413.34. | |
| Spectinomycin dihydrochloride | Spectinomycin dihydrochloride is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride is also a noncompetitive inhibitor of td intron RNA with an K i value of 7.2 mM [1] - [5]. Uses: Scientific research. Group: Natural products. CAS No. 21736-83-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 25 g. Product ID: HY-B0438. | |
| Spectinomycin dihydrochloride pentahydrate | Spectinomycin dihydrochloride pentahydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride pentahydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride pentahydrate is also a noncompetitive inhibitor of td intron RNA with an K i value of 7.2 mM [1] - [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Spectinomycin hydrochloride hydrate. CAS No. 22189-32-8. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B1828A. | |
| Inolitazone dihydrochloride | In vitro, the IC50 for growth inhibition is approximately 0.8 nM while anaplastic thyroid carcinoma (ATC) tumor growth was inhibited three- to fourfold in nude mice. siRNA against PPARgamma and a pharmacological antagonist demonstrated that functional PPARgamma was required for growth inhibitory activity of RS5444. RS5444 upregulated the cell cycle kinase inhibitor, p21WAF1/CIP1. RS5444inhibited culture growth and caused irreversible G1 arrest, but did not induce apoptosis. In addition, RS5444 caused dramatic changes in cellular morphology which were associated with increased motility and diminished cellular adherence, but no increase in the ability of such cells to digest and invade Matrigel. Treatment with RS5444 leads to the up-regulation of RhoB and subsequent activation of p21, and that silencing of RhoB by RNAi blocks the ability of RS5444 to induce p21 and to inhibit ATC cells proliferation. The median peak efatutazone blood level was 8.6 ng/mL for 0.15-mg dosing vs 22.0 ng/mL for 0.3-mg twice daily dosing. Although efatutazone treatment did not reduce percentage of mice developing invasive cancer, it significantly reduced prevalence of noninvasive cancer and total number of cancers per mouse and increased prevalence of well-differentiated cancer subtypes not usually seen in this mouse model. Uses: Antineoplastic agents. Synonyms: Efatutazone; Efatutazone hydrochloride; CS 7017; CS-7017; CS7017 ;RS-5444; RS5444; UNII-76B44WEA8O. Grades: >98%. CAS No. 223132-38-5. Molecular formula: C27H28Cl2N4O4S. Mole weight: 575.51. | |
Our database is helping our users find suppliers everyday.
