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| Product | Description | |
|---|---|---|
| RN-1734 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| RN-1734 | RN-1734 is selective antagonist of the TRPV4 channel. It completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50values for all three species with IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively. It is selective for TRPV4 in a TRP selectivity panel, thus is used as a valuable pharmacological probe for TRPV4 studies. It blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo. Uses: Rn-1734 is used as a valuable pharmacological probe for trpv4 studies. Synonyms: RN1734; RN 1734; RN-1734; 2, 4-Dichloro-N-isopropyl-N- (2-isopropylaminoethyl) benzenesulfonamide; 2, 4-Dichloro-N-propan-2-yl-N-[2- (propan-2-ylamino) ethyl]benzenesulfonamide; 2, 4-Dichloro-N- (1-methylethyl) -N-[2-[ (1-methylethyl) amino]ethyl]benzenesulfonamide. Grades: 95%. CAS No. 946387-07-1. Molecular formula: C14H22Cl2N2O2S. Mole weight: 353.31. |  |
| TRPV4 Antagonist I, RN-1734 (2, 4-Dichloro-N-isopropyl-N- (2-isopropylaminoethyl) benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734) | A cell-permeable benzenesulfonamide compound that selectively antagonizes TRPV4 agonist 4a-PDD-stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9uM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 946387-07-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 | The TRPV4 Antagonist I, RN-1734, also referenced under CAS 946387-07-1, controls the biological activity of TRPV4. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| RN 1747 | RN 1747, a selective TRPV4 agonist (EC50= 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively), represents the first drug-like TRPV4 antagonist with selectivity over closely related TRP channels. The activities of these compounds were characterized using two different systems: Ca2+ influx assay with human, mouse and rat TRPV4-expressing HEK293 cells and electrophysiology in hTRPV4-transfected Xenopus oocytes. Importantly, RN-1734 antagonized both ligand-gated activation and hypotonicity-induced opening of TRPV4 in both types of assay. Synonyms: Piperazine, 1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-; 1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)piperazine; RN1747; RN-1747; 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine. Grades: ≥95%. CAS No. 1024448-59-6. Molecular formula: C17H18ClN3O4S. Mole weight: 395.87. | |
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