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| Product | Description | |
|---|---|---|
| RN-1734 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| RN-1734 | RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4?PDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 ?M, mTRPV4: 5.9 ?M, rTRPV4: 3.2 ?M)[1]. RN-1734 clearly decreases the production of tumor necrosis factor ? (TNF-?) and interleukin 1? (IL-1?) without altering the number of olig2-positive cells[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 946387-07-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19975. |  |
| TRPV4 Antagonist I, RN-1734 (2, 4-Dichloro-N-isopropyl-N- (2-isopropylaminoethyl) benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734) | A cell-permeable benzenesulfonamide compound that selectively antagonizes TRPV4 agonist 4a-PDD-stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9uM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 946387-07-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 | The TRPV4 Antagonist I, RN-1734, also referenced under CAS 946387-07-1, controls the biological activity of TRPV4. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
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