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| Product | Description | |
|---|---|---|
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates. Synonyms: RO0335; RO 0335; N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoroBenzeneacetamide. Grades: 99%. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.21. |  |
| RO-0335 | RO-0335 is a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Two pathways to loss of susceptibility to RO-0335 were observed, containing patterns of amino acid changes at either V106I/A plus F227C (with additional contributions from A98G, V108I, E138K, M230L and P236L) or V106I/Y188L (with a potential contribution from L100I, E138K and Y181C). Characterization of the observed mutations by site-directed mutagenesis in the isogenic HXB2D background demonstrated that a minimum of two or more mutations were required for significant loss of susceptibility, with the exception of Y188L, which requires a two-nucleotide change. Patterns containing F227C or quadruple mutations selected by RO-0335 showed a low relative fitness value when compared to wild-type HXB2D. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RO0335; RO-0335; RO 0335. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 867365-76-2. Molecular formula: C21H13BrCl2FN3O4S. Mole weight: 573.22. Purity: >98%. IUPACName: 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide. Canonical SMILES: O=C(NC1=CC=C(S(=O)(N)=O)C=C1Cl)CC2=CC=C(Br)C(OC3=CC(C#N)=CC(Cl)=C3)=C2F. Product ID: ACM867365762. Alfa Chemistry ISO 9001:2015 Certified. |  |
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