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| Product | Description | |
|---|---|---|
| Ro5-3335 | Ro5-3335 Inhibitor. Uses: Scientific use. Product Category: T4687. CAS No. 30195-30-3. |  |
| CBF beta-Runx1 Inhibitor II, Ro5-3335 ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one], Ro53335, CBFalpha-CBFbeta Inhibitor II) | A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| WUN40378 | WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of Ro 24-7429. Uses: Designed for use in research and industrial production. Additional or Alternative Names: WUN40378; WUN 40378; WUN-40378; Ro5-3335 analog; Ro 5-3335 analog; Ro 5-3335 analog; Ro 24-7429 analog; Ro 24-7429 analog; Ro24-7429 analog. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2328140-37-8. Molecular formula: C13H10FN3O. Mole weight: 243.24. Purity: >98%. IUPACName: 7-fluro-1,3-dihydro-5-(1H-pyrrol-2yl)-2H-1,4-benzodiazepin-2-one. Canonical SMILES: O=C1NC2=CC=C(F)C=C2C(C3=CC=CN3)=NC1. Product ID: ACM2328140378. Alfa Chemistry ISO 9001:2015 Certified. |  |
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