Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Rolofylline | Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 ( CYP 450 ) [1]. Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KW-3902. CAS No. 136199-02-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10965. |  |
| Rolofylline metabolite M1-cis | Rolofylline metabolite M1-cis, an active metabolite of Rolofylline, is a potent and selective adenosine A1 receptor antagonist. Synonyms: Rolofylline metabolite M1-cis; Rolofylline metabolite M1-trans; 160943-06-6; 161167-65-3; SCHEMBL3263501; L011792; 8-(Hexahydro-7-hydroxy-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-Purine-2,6-dione, cis; 8-(Hexahydro-7-hydroxy-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-Purine-2,6-dione, trans. Grades: 98%. CAS No. 161167-65-3. Molecular formula: C20H28N4O3. Mole weight: 372.46. |  |
| Rolofylline metabolite M1-trans | Rolofylline metabolite M1-trans, an active metabolite of Rolofylline, is a potent and selective adenosine A1 receptor antagonist. Grades: 99%. CAS No. 160943-06-6. Molecular formula: C20H28N4O3. Mole weight: 372.46. | |
| KW-3902 | KW-3902 is a selective adenosine A1 receptor antagonist under the development of Kyowa Hakko and Merck & Co. It displays 890-fold selectivity for rat A1 receptors over A2A receptors. (Ki value for adenosine A1 is 0.19 nM; 170 nM for adenosine A2A ). KW-3902 exhibits diuretic and renal protective effects in rats. Clinical trials for the treatment of Acute heart failure, Cognition disorders and Hypertension was discontinued. Uses: Acute heart failure; cognition disorders; hypertension. Synonyms: 1,3-dipropyl-8-(3-noradamantyl)xanthine, 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione, KW-3902; KW 3902; KW3902; Rolofylline. Grades: 98%. CAS No. 136199-02-5. Molecular formula: C20H28N4O2. Mole weight: 356.46. | |
Our database is helping our users find suppliers everyday.
