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| Product | Description | |
|---|---|---|
| Romidepsin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. Alternative Names: NSC 630176, Romidepsin, Istodax, FR 901228, 2-Oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricosane, cyclic peptide deriv.,Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3->5)-disulfide, Antibiotic FR 901228, Chromadax, FK 228, L-Valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-, (4->1)-lactone, cyclic (1->2)-disulfide, [S-(E)]-. |  |
| Romidepsin | Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC 50 s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively [1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FK 228; FR 901228; NSC 630176. CAS No. 128517-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15149. |  |
| Romidepsin | Romidepsin. Group: Biochemicals. Alternative Names: (1S,4Z,7S,10S,11E,20R)-4-Ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3, 6, 18, 21-tetrazabicyclo[8. 7. 6]tricos-11-ene-2, 5, 8, 19, 22-pentone; Depsipeptide; FK228. Grades: Highly Purified. CAS No. 128517-07-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C24H36N4O6S2. US Biological Life Sciences. |  Worldwide |
| Romidepsin | Romidepsin Inhibitor. Uses: Scientific use. Product Category: T6006. CAS No. 128517-07-7. |  |
| Romidepsin | Romidepsin strongly inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 25 nM and 790 nM, respectively. Uses: For research used only. Synonyms: Istodax; FK228; FK 228; FK-228; Chromadax; Antibiotic FR 901228; FR901228; FR-901228; NSC-630176; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide. Grades: >98%. CAS No. 128517-07-7. Molecular formula: C24H36N4O6S2. Mole weight: 540.69. |  |
| LY2409881 | LY2409881 is a novel selective inhibitor of IKK2. It inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. It suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs. Synonyms: LY2409881; LY 2409881; LY-2409881. Grades: >98%. CAS No. 946518-61-2. Molecular formula: C24H29ClN6OS. Mole weight: 485.04. | |
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