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| Product | Description | |
|---|---|---|
| Roquinimex | Roquinimex, also known as LS 2616 and FCF89 (brande name: Linomide), is a quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. Check for active clinical trials or closed clinical trials using this agent. Synonyms: FCF89; FCF-89; FCF 89; LS2616; LS-2616; LS 2616; Quinoline-3-carboxamide; CCRIS 7673; Linomide. Grades: >98%. CAS No. 84088-42-6. Molecular formula: C18H16N2O3. Mole weight: 308.33. |  |
| Roquinimex | Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.IC50 value:Target: TNF alphaProphylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity. Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE;ROQUINIMEX;LINOMIDE;LS-2616;1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE;4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hy |  |
| Roquinimex | Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Linomide; FCF89; ABR212616. CAS No. 84088-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13743. |  |
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