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| Product | Description | |
|---|---|---|
| Rp-8-pCPT-cGMPS | Rp-8-pCPT-cGMPS is a selective inhibitor of protein kinase G I a, I ß and especially of type II, which stimulates retinal cGMP channels and discriminates between kinase and channel effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-cGMPS or Rp-8-Br-cGMPS, it exhibits more lipophilic and membrane-permeant properties. Synonyms: 8- (4- Chlorophenylthio)guanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 153660-04-9. Molecular formula: C16H14ClN5O6PS2 · Na. Mole weight: 525.9. |  |
| Rp-8-pCPT-cGMPS sodium | Rp-8-pCPT-cGMPS sodium, a stable, cell-permeable cGMP analog, is a PKG inhibitor (Ki= 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Synonyms: 8-[(4-Chlorophenyl)thio]-guanosine-cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] sodium; Rp-8-pCPT-cGMPS. Grades: ≥99% by HPLC. CAS No. 208445-07-2. Molecular formula: C16H14ClN5NaO6PS2. Mole weight: 525.86. | |
| Rp-8-Br-PET-cGMPS | Rp-8-Br-PET-cGMPS is a selective inhibitor of cGMP-dependent protein kinase I a and I β and of retinal cGMP-gated ion channels. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to Rp-8-pCPT-cGMPS, it is much more lipophilic and membrane-permeant. Synonyms: 8- Bromo- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, sodium salt. Grades: ≥ 99% by HPLC. CAS No. 172806-20-1. Molecular formula: C18H14BrN5O6PS · Na. Mole weight: 562.3. | |
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