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| Product | Description | |
|---|---|---|
| RPI-1 | RPI-1 is a cell-permeable, ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. It can also be used in biological study of proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations and identification of new signaling elements. Synonyms: 1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one; RPI-1; RPI1; RPI 1. CAS No. 269730-03-2. Molecular formula: C17H15NO4. Mole weight: 297.31. |  |
| RPI-1 | RPI-1 is a specific, orally available 2-indolinone Ret tyrosine kinase inhibitor. RPI-1 inhibits proliferation, Ret tyrosine phosphorylation, Ret protein expression, and the activation of PLCgamma, ERKs and AKT in human medullary thyroid carcinoma TT cells. Antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 269730-03-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101246. |  |
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