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| Product | Description | |
|---|---|---|
| RS-102221 | RS-102221 is a drug developed by Hoffmann-La Roche, which was one of the first compounds discovered that acts as a potent and selective antagonist at the serotonin 5-HT2C receptor, with around 100x selectivity over the closely related 5-HT2A and 5-HT2B receptors. It has anxiolytic effects in animal studies, increases the effectiveness of SSRI antidepressants, and shows a complex interaction with cocaine, increasing some effects but decreasing others, reflecting a role for the 5-HT2C receptor in regulation of the dopamine signalling system in the brain. Synonyms: RS 102221; RS102221; N-{5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)pentanoyl]-2,4-dimethoxyphenyl}-4-trifluoromethylbenzenesulfonamide. Grades: 98%. CAS No. 185376-97-0. Molecular formula: C27H31F3N4O7S. Mole weight: 612.62. |  |
| RS-102221 hydrochloride | RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (K i =10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 187397-18-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101365A. |  |
| RS 102221 hydrochloride | RS 102221 is a selective 5-HT2C receptor antagonist (pKi = 8.7), and demonstrates nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. Synonyms: RS-102221 HCl; RS102221 HCl; RS 102221 HCl; 8-[5- (2, 4-Dimethoxy-5- (4-trifluoromethylphenylsulphonamido) phenyl-5-oxopentyl]-1, 3, 8-triazaspiro[4. 5]decane-2, 4-dione hydrochloride; N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)-benzenesulfonamide Monohydrochloride (9CI). Grades: ≥98% by HPLC. CAS No. 187397-18-8. Molecular formula: C27H31F3N4O7S.HCl. Mole weight: 649.08. | |
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