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| Product | Description | |
|---|---|---|
| Ruboxistaurin | Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Synonyms: 13-((dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione; Arxxant; LY 333531; LY-333531; LY333531; ruboxistaurin; ruboxistaurin mesilate hydrate. CAS No. 169939-94-0. Molecular formula: C28H28N4O3. Mole weight: 468.557. |  |
| Ruboxistaurin | Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor ( K i =2 nM). Ruboxistaurin exhibits ATP dependent competitive inhibition of PKC beta I with an IC 50 of 4.7 nM. Ruboxistaurin inhibits PKC beta II with an IC 50 of 5.9 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY333531. CAS No. 169939-94-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10195. |  |
| Ruboxistaurin HCl | Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Uses: Enzyme inhibitors. Synonyms: Ruboxistaurin Hydrochloride; LY-333531 hydrochloride; Ruboxistaurin (hydrochloride); 169939-93-9; LY 333531 hydrochloride; LY333531 hydrochloride; Ruboxistaurin-d6 Hydrochloride; 169939-94-0 (base). Grades: > 95%. CAS No. 169939-93-9. Molecular formula: C28H28N4O3.HCl. Mole weight: 505.01. | |
| Ruboxistaurin hydrochloride | Ruboxistaurin hydrochloride. Group: Biochemicals. Alternative Names: (9S) -9-[ (Di methyl amino) methyl ]-6, 7, 10, 11-tetra hydro-9H, 18H-5, 21: 12, 17-dimethenodibenzo [e, k ] pyrrolo [3, 4-h] [1, 4, 13] oxadiaz acyclohexadecine-18, 20 (19H) -dione hydrochloride; LY 333531. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C28H29ClN4O3. US Biological Life Sciences. |  Worldwide |
| Ruboxistaurin hydrochloride | Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor ( K i =2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC 50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC 50 of 5.9 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY333531 hydrochloride. CAS No. 169939-93-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10195B. | |
| Ruboxistaurin mesylate | Ruboxistaurin (LY333531) mesylate is an orally active, selective and ATP competitive PKCβ inhibitor with IC 50 values of 4.7 and 5.9 nM for PKCβI and PKCβII, respectively. Ruboxistaurin mesylate can be used for the research of eye disorders, heart failure and diabetes [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY333531 mesylate. CAS No. 192050-59-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-10195A. | |
| LY-333,531 hydrochloride (Ruboxistaurin) | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| LY 333531 mesylate | LY 333531 mesylate is an orally-available protein kinase C β (PKC-β) specific inhibitor used for the treatment of diabetic nephropathy and diabetic macular edema. Uses: The treatment of diabetic nephropathy and diabetic macular edema. Synonyms: LY 333531 mesylate; LY333531 mesylate; LY-333531 mesylate; Ruboxistaurin mesylate; (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione mesylate. Grades: 99%. CAS No. 192050-59-2. Molecular formula: C28H28N4O3.CH4O3S. Mole weight: 564.65. | |
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