Ruboxistaurin Suppliers USA
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Product | Description | |
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Ruboxistaurin Quick inquiry Where to buy Suppliers range | Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Synonyms: 13-((dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione; Arxxant; LY 333531; LY-333531; LY333531; ruboxistaurin; ruboxistaurin mesilate hydrate. CAS No. 169939-94-0. Molecular formula: C28H28N4O3. Mole weight: 468.557. | |
Ruboxistaurin HCl Quick inquiry Where to buy Suppliers range | Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Uses: Enzyme inhibitors. Synonyms: Ruboxistaurin Hydrochloride; LY-333531 hydrochloride; Ruboxistaurin (hydrochloride); 169939-93-9; LY 333531 hydrochloride; LY333531 hydrochloride; Ruboxistaurin-d6 Hydrochloride; 169939-94-0 (base). Grades: > 95%. CAS No. 169939-93-9. Molecular formula: C28H28N4O3.HCl. Mole weight: 505.01. | |
Ruboxistaurin hydrochloride Quick inquiry Where to buy Suppliers range | Ruboxistaurin hydrochloride. Group: Biochemicals. Alternative Names: (9S) -9-[ (Di methyl amino) methyl ]-6, 7, 10, 11-tetra hydro-9H, 18H-5, 21: 12, 17-dimethenodibenzo [e, k ] pyrrolo [3, 4-h] [1, 4, 13] oxadiaz acyclohexadecine-18, 20 (19H) -dione hydrochloride; LY 333531. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C28H29ClN4O3. US Biological Life Sciences. | Worldwide |
LY-333,531 hydrochloride (Ruboxistaurin) Quick inquiry Where to buy Suppliers range | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
LY 333531 mesylate Quick inquiry Where to buy Suppliers range | LY 333531 mesylate is an orally-available protein kinase C β (PKC-β) specific inhibitor used for the treatment of diabetic nephropathy and diabetic macular edema. Uses: The treatment of diabetic nephropathy and diabetic macular edema. Synonyms: LY 333531 mesylate; LY333531 mesylate; LY-333531 mesylate; Ruboxistaurin mesylate; (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione mesylate. Grades: 99%. CAS No. 192050-59-2. Molecular formula: C28H28N4O3.CH4O3S. Mole weight: 564.65. |