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| Product | Description | |
|---|---|---|
| Ruboxistaurin hydrochloride | Ruboxistaurin hydrochloride. Group: Biochemicals. Alternative Names: (9S) -9-[ (Di methyl amino) methyl ]-6, 7, 10, 11-tetra hydro-9H, 18H-5, 21: 12, 17-dimethenodibenzo [e, k ] pyrrolo [3, 4-h] [1, 4, 13] oxadiaz acyclohexadecine-18, 20 (19H) -dione hydrochloride; LY 333531. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C28H29ClN4O3. US Biological Life Sciences. |  Worldwide |
| Ruboxistaurin hydrochloride | Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor ( K i =2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC 50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC 50 of 5.9 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY333531 hydrochloride. CAS No. 169939-93-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10195B. |  |
| LY-333,531 hydrochloride (Ruboxistaurin) | An isozyme-selective inhibitor of protein kinase Cb (PKCb). Inhibits both the PKCbI (IC??=4.7 nM) and PKCbII (IC??=5.9nm) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of PKCbI and PKCbII over PKCa. Group: Biochemicals. Grades: Highly Purified. CAS No. 169939-93-9. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Ruboxistaurin HCl | Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-maximal inhibitory constant of 4.5 and 5.9 nM, respectively. The half-life of ruboxistaurin, which can be orally administered, is approximately 9h and that of its metabolite 16h, therefore allowing once-daily dosing. Based on data from clinicalTrials.gov, Children's Hospital Medical Center, Cincinnati plan a phase I/II trial of the effect of ruboxistaurin for its safety, tolerability, and effectiveness in treating adult patients with heart failure on June 9, 2016. Uses: Enzyme inhibitors. Synonyms: Ruboxistaurin Hydrochloride; LY-333531 hydrochloride; Ruboxistaurin (hydrochloride); 169939-93-9; LY 333531 hydrochloride; LY333531 hydrochloride; Ruboxistaurin-d6 Hydrochloride; 169939-94-0 (base). Grades: > 95%. CAS No. 169939-93-9. Molecular formula: C28H28N4O3.HCl. Mole weight: 505.01. |  |
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