Rucaparib Suppliers USA
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Product | Description | |
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Rucaparib Quick inquiry Where to buy Suppliers range | Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. So, rucaparib has been also found to be most effective in cells deficient in DNA repair, where the cells deficient are caused by exposure to genotoxic agents, such as irradiation produces DNA damage and its toxicity is augmented when the DNA repair is impaired. Increased radiosensitivity in presence of rucaparib was associated with persistent DNA breaks as determined by gamma-H2AX and p53BP1 foci. Rucaparib radiosensitizes prostate cancer cells, most effectively those that are PTEN-deficient and are expressing ETS gene fusion proteins, which inhibits NHEJ DNA repair. Uses: Cancer therapy. Synonyms: 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one; Rucaparib free base, AG-14447; AG 14447; AG14447; Rubraca. Grades: >98%. CAS No. 283173-50-2. Molecular formula: C19H18FN3O. Mole weight: 323.36. | |
Rucaparib Camsylate Quick inquiry Where to buy Suppliers range | Rucaparib camsylate is a PARP inhibitor. Synonyms: Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:x); 8-fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate (1:x); 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid (1:x). Grades: ≥98% by HPLC. CAS No. 1327258-57-0. Molecular formula: C19H18FN3O.xC10H16O4S. Mole weight: 323.37 (free base). | |
Rucaparib phosphate Quick inquiry Where to buy Suppliers range | Rucaparib Phosphate is a selective PARP inhibitor that suppresses the PARP1-mediated DNA repair via binding to PARP1 (Ki = <5 nM). It can be used to sensitize cancer cells to chemotherapy as an antineoplastic agent. Uses: Antineoplastic agent. Synonyms: AG-014699; PF-01367338; AG 014699; PF 01367338; AG014699; PF01367338; Rucaparib (phosphate). Grades: >98%. CAS No. 459868-92-9. Molecular formula: C19H21FN3O5P. Mole weight: 421.365. |