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| Product | Description | |
|---|---|---|
| Ruxolitinib phosphate | Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC 50 s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB018424 phosphate. CAS No. 1092939-17-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50858. |  |
| Ruxolitinib Phosphate | Used for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. It has a role as an antineoplastic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. Alternative Names: Jakafi;Jakavi;(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate. CAS No. 1092939-17-7. Product ID: API1092939177. Molecular formula: C17H21N6O4P. Mole weight: 404.4. EINECS: 641-390-8. SMILES: C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O. Standard: Facility GMP. Category: Anti-Tumor APIs. |  |
| (S)-Ruxolitinib Phosphate | (S)-Ruxolitinib Phosphate is an impurity of Ruxolitinib phosphate. Ruxolitinib phosphate is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Synonyms: Ruxolitinib (S)-Isomer Phosphate; (S)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile Phosphate. Grade: 95%. CAS No. 2703484-89-1. Molecular formula: C17H21N6O4P. Mole weight: 404.37. |  |
| Ruxolitinib | Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. It has a role as an antineoplastic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. Alternative Names: INCB018424. Ruxolitinib (INCB018424). (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile. CAS No. 941678-49-5. Product ID: API941678495. Molecular formula: C17H18N6. Mole weight: 306.4. SMILES: C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3. Appearance: Colorless oil. Category: Anti-Tumor APIs. | |
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