Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| RyR-Calstabin Interaction Stabilizer, S107 (7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107) | A cell-permeable, orally active benzothiazepine that effectively blocks leaky intracellular calcium release by preventing the dissociation/depletion of calstabin from the ryanodine receptor (RyR) complex due to receptor modifications, such as oxidation, S-nitrosylation, hyperphosphorylation, or mutation (complete blockage of 1 mM tetracaine-induced leakage in murine RyR2 S2808D+/+ myocytes at 1uM). Shown to prevent stress-induced cognitive dysfunction by stabilizing RyR2-calstabin-2 (FKBP12.6) interaction in brain (75mg/kg/day; p.o.) and maintain exercise capacity by stabilizing RyR1-calstabin-1 (FKBP12) interaction in skeletal muscle (2. 5ug/0. 25uL/h/animal; s.c) in mice, as well as restore normal cardiac function (20mg/kg/day; s.c) in mice with R2474S or S2808D RyR2 mutation in vivo.Primary Target:RyR2. Group: Biochemicals. Alternative Names: 7-methoxy-4-methyl-2, 3, 4, 5-tetrahydrobenzo[f][1, 4]thiazepine, Ryanodine Receptor Stabilizer; Rycal S107. Grades: Highly Purified. CAS No. 927871-76-9. Pack Sizes: 10mg. Molecular Formula: C??H??NOS, Molecular Weight: 209.3. US Biological Life Sciences. |  Worldwide |
Our database is helping our users find suppliers everyday.
