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| Product | Description | |
|---|---|---|
| S1RA | S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with K i s of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT 2B receptor (K i = 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-52862. CAS No. 878141-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-18099. |  |
| S1RA | The sigma-1 (σ1) receptor is an intracellular, non-opioid receptor that is abundantly expressed in the central nervous system as well as peripherally. S1RA is a potent, selective antagonist of σ1 receptors (Ki = 17 nM) that weakly binds σ2 receptors (Ki = 9,300 nM). Synonyms: S1RA; 878141-96-9; E-52862; ZW18DSD1H4; 4-(2-((5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yl)oxy)ethyl)morpholine;4-[2-[[5-methyl-1-(2-naphthalenyl)-1h-pyrazol-3-yl]oxy]ethyl] morpholine; 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholine; MORPHOLINE, 4-(2-((5-METHYL-1-(2-NAPHTHALENYL)-1H-PYRAZOL-3-YL)OXY)ETHYL)-. CAS No. 878141-96-9. Molecular formula: C20H23N3O2. Mole weight: 337.42. |  |
| S1RA hydrochloride | S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor ( σ1R ) antagonist with a K i value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (K i >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC 50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-52862 hydrochloride. CAS No. 1265917-14-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-18099A. | |
| S1RA Hydrochloride | The hydrochloride salt form of S1RA which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. It is still under Phase II clinical trial. IC50: 17 nM (Ki). Uses: The hydrochloride salt form of s1ra which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. Synonyms: S1RA hydrochloride; S1RA (hydrochloride); E-52862 hydrochloride; E 52862 hydrochloride; E52862 hydrochloride; SCHEMBL99116; UNII-18XZ7850YN. Grades: 98%. CAS No. 1265917-14-3. Molecular formula: C20H24ClN3O2. Mole weight: 373.88. | |
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