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| Product | Description | |
|---|---|---|
| Saccharocarcin A | An unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcin and versipelostatin; has pronounced activity against gram positive bacteria and chlamydia trachomatis; inhibits transcription from the promoter of GRP78; appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: 10-[[4-(acetylamino)-2,4,6-trideoxy-3-C-methylhexopyranosyl]oxy]-4-[[O-2,6-dideoxyhexopyranosyl-(1?4)-O-2,6-dideoxy-3-O-(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)hexopyranosyl-(1?4)-2,6-dideoxyhexopyranosyl]oxy]-15-ethyl-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,3,7,9,11,20a-hexamethyl-18H-16a,19-metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione. Grades: >95% by HPLC. CAS No. 158475-32-2. Molecular formula: C67H101NO20. Mole weight: 1240.51. |  |
| Saccharocarcin A | Saccharocarcin A is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcin and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. Limited availability has restricted further investigation of this metabolite in the literature. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 158475-32-2. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Saccharocarcin B | An unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcin and versipelostatin; has pronounced activity against gram positive bacteria and chlamydia trachomatis; inhibits transcription from the promoter of GRP78; appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: 10-[[4-(acetylamino)-2,4,6-trideoxy-3-C-methylhexopyranosyl]oxy]-4-[[O-2,6-dideoxyhexopyranosyl-(1?4)-O-2,6-dideoxy-3-O-(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)hexopyranosyl-(1?4)-2,6-dideoxyhexopyranosyl]oxy]-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,3,7,9,11,20a-hexamethyl-15-propyl-18H-16a,19-metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione. Grades: >99% by HPLC. CAS No. 158475-33-3. Molecular formula: C68H103NO20. Mole weight: 1254.54. | |
| Saccharocarcin B | Saccharocarcin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and Chlamydia trachomatis. Limited availability has restricted further investigation of this metabolite in the literature. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 158475-33-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Chlorothricin | Chlorothricin is produced by the strain of Streptomyces antibioticus Tu 99. Related to kijanimicin, saccharocarcins, tetrocarcins and versipelostatin. It inhibits cholesterol biosynthesis from mevalonate, and inhibits pyruvate carboxylases purified from rat liver, chicken liver and azotobacter vinelandii. Synonyms: (4S, 4aS, 6aR, 11E, 12aR, 15R, 16aS, 21aR, 21bR)-4-[[4-O-[3-O-(3-Chloro-6-methoxy-2-methylbenzoyl)-2, 6-dideoxy-β-D-arabino-hexopyranosyl]-2, 6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1, 2, 3, 4, 4a, 6a, 7, 8, 9, 10, 12a, 15, 16, 21, 21a, 21b-hexadecahydro-22-hydroxy-15, 21a-dimethyl-18, 21-dioxo-18H-16a, 19-metheno-16aH-benzo[e]naphtho[2, 1-m][1, 4]dioxacyclopentadecin-14-carboxylic Acid; [4S-(4R*, 4aR*, 6aS*, 11E, 12aS*, 15S*, 16aR*, 21aS*, 21bS*)]-4-[[4-O-[3-O-(3-Chloro-6-methoxy-2-methylbenzoyl)-2, 6-dideoxy-β-D-arabino-hexopyranosyl]-2, 6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1, 2, 3, 4, 4a, 6a, 7, 8, 9, 10, 12a, 15, 16, 21, 21a, 21b-hexadecahydro-22-hydroxy-15, 21a-dimethyl-18, 21-dioxo-18H-16a, 19-metheno-16aH-benzo[e]naphtho[2, 1-m][1, 4]dioxacyclopentadecin-14-carboxylic Acid. Grades: >99% by HPLC. CAS No. 34707-92-1. Molecular formula: C50H63ClO16. Mole weight: 955.48. | |
| Kijanimicin | A tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin; contains an unusual nitroaminoglycoside; a potent antibacterial, antimalarial and antitumour active; inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). Synonyms: NSC 329515; Sch 25663. Grades: >99% by HPLC. CAS No. 78798-08-0. Molecular formula: C67H100N2O24. Mole weight: 1317.51. | |
| Kijanimicin (Antibiotic Sch 25663) | Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitro-aminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor activity. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. While tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway. Group: Biochemicals. Alternative Names: Antibiotic Sch 25663. Grades: Highly Purified. CAS No. 78798-08-0. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Tetromycin A | An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: [1S-(1R*, 4R*, 4aR*, 6aS*, 7E, 11E, 12aS*, 15S*, 16aR*, 20aR*, 20bS*)]-4-(acetyloxy)-2, 3, 4, 4a, 6a, 9, 10, 12a, 15, 16, 20a, 20b-dodecahydro-21-hydroxy-1, 6, 7, 11, 12a, 14, 15, 20a-octamethyl-18H-16a, 19-Metheno-16aH-benzo[b]naphth[2, 1-j]oxacyclotetradecin-18, 20(1H)-dione; 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide 9-Acetate. Grades: >99% by HPLC. CAS No. 180027-83-2. Molecular formula: C36H48O6. Mole weight: 576.76. | |
| Tetromycin A | Tetromycin A is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin A has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'- kinase/Akt signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 180027-83-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Tetromycin B | An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide; [1S-(1R*, 4R*, 4aR*, 6aS*, 7E, 11E, 12aS*, 15S*, 16aR*, 20aR*, 20bS*)]-2, 3, 4, 4a, 6a, 9, 10, 12a, 15, 16, 20a, 20b-Dodecahydro-4, 21-trihydroxy-1, 6, 7, 11, 12a, 14, 15, 20a-octamethyl-18H-16a, 19-metheno-16aH-benzo[b]naphth[2, 1-j]oxacyclotetradecin-18, 20(1H)-dione. Grades: >99% by HPLC. CAS No. 180027-84-3. Molecular formula: C34H46O5. Mole weight: 534.73. | |
| Tetromycin B | Tetromycin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin B has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'- kinase/Akt signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 180027-84-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
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