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| Product | Description | |
|---|---|---|
| SAH-SOS1A | SAH-SOS1A is a cell-permeable, stabilized hydrocarbon-stapled alpha helical peptide that acts as a K-Ras/son of sevenless 1 (SOS1) interaction inhibitor. It binds within nucleotide binding pocket of wild-type and mutant K-Ras. CAS No. 1652561-87-9. Molecular formula: C100H159N27O28. Mole weight: 2187.53. |  |
| SAH-SOS1A TFA | SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS [1]. Uses: Scientific research. Group: Peptides. CAS No. 2896737-31-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2265A. |  |
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