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| Product | Description | |
|---|---|---|
| SAR125844 | SAR125844 is a potent, selective, and ATP-competitive MET kinase inhibitor with the value of IC 50 is 4.2 nM and K i is 2.8 nM. SAR125844 has antitumor activity and can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1116743-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16446. |  |
| SAR125844 | SAR125844 is inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. Upon intravenous administration, c-Met inhibitor SAR125844 binds to c-Met, thereby disrupting c-Met-mediated signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of cancers, plays an important role in tumor cell proliferation, survival, invasion, metastasis and tumor angiogenesis. Synonyms: SAR 125844; SAR-125844; 1-(6-((6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea; Urea, N-[6-[[6-(4-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]-2-benzothiazolyl]-N'-[2-(4-morpholinyl)ethyl]-. Grades: >98%. CAS No. 1116743-46-4. Molecular formula: C25H23FN8O2S2. Mole weight: 550.63. |  |
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