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| Product | Description | |
|---|---|---|
| SAR407899 | SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC 50 of 135 nM for ROCK-2 , and K i s of 36 nM and 41 nM for human and rat ROCK-2 , respectively. SAR407899 shows stable inhibition of migrasome formation. Uses: Scientific research. Group: Signaling pathways. CAS No. 923359-38-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15687A. |  |
| SAR407899 hydrochloride | SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC 50 of 135 nM for ROCK-2 , and K i s of 36 nM and 41 nM for human and rat ROCK-2 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 923262-96-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15687. | |
| SAR-407899 | SAR-407899 is a potent, ATP-competitive ROCK inhibitor. It is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. It is highly selective in panel of 117 receptor and enzyme targets in vitro. It demonstrated concentration-dependent inhibition of Rho-kinase-mediated phosphorylation of myosin phosphatase, platelet-derived growth factor-induced proliferation, thrombin-induced stress fiber formation, and monocyte chemotactic protein-1-stimulated chemotaxis in vitro. It potently inhibits endothelin-1-induced constriction of renal resistance arteries. It has good antihypertensive activity and lowered blood pressure in a variety of rodent models. Uses: Sar-407899 has good antihypertensive activity. Synonyms: SAR407899; SAR 407899; SAR-407899; 6-Piperidin-4-yloxy-2H-isoquinolin-1-one;6-(Piperidin-4-yloxy)isoquinolin-1(2H)-one. Grades: >98 %. CAS No. 923359-38-0. Molecular formula: C14H16N2O2. Mole weight: 244.29. |  |
| SAR-407899 hydrochloride | SAR-407899 hydrochloride is the hydrochloride form of SAR-407899, which is a potent, ATP-competitive ROCK inhibitor. It has good antihypertensive activity. Uses: Sar-407899 hydrochloride has good antihypertensive activity. Synonyms: 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride; SAR407899; SAR 407899; SAR-407899; SAR407899 HCl. Grades: >98%. CAS No. 923262-96-8. Molecular formula: C14H17ClN2O2. Mole weight: 280.75. | |
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