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| Product | Description | |
|---|---|---|
| Sardomozide | Sardomozide, also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2. The in vivo phosphorylation of p53 at residues Ser(46)/Ser(392) and Mdm2 at residue Ser(166) was observed. SAM486A may be effective alternative agents for the treatment of NBs with or without MYCN amplification. Uses: Antineoplastic agents. Synonyms: CGP 48664; CGP-48664; CGP48664; SAM 486A; SAM-486A; SAM486A. Grades: >98%. CAS No. 149400-88-4. Molecular formula: C11H14N6. Mole weight: 230.27. |  |
| Sardomozide dihydrochloride | Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase ( SAMDC ) inhibitor with an IC 50 of 5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGP 48664A. CAS No. 138794-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-13746B. |  |
| Sardomozide HCl | Sardomozide , also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). Synonyms: Sardomozide 2HCl; Sardomozide dihydrochloride; 2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride. Grades: 98%. CAS No. 138794-73-7. Molecular formula: C11H16Cl2N6. Mole weight: 303.19. | |
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