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| Product | Description | |
|---|---|---|
| SB 203580 | SB 203580 Inhibitor. Uses: Scientific use. Product Category: T1764. CAS No. 152121-47-6. |  |
| SB 203580 | solid, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SB 203580 - CAS 152121-47-6 | SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC?? = 34 nM in vitro, 600 nM in cells). Group: Fluorescence/luminescence spectroscopy. | |
| SB 203580 hydrochloride | SB 203580 hydrochloride is a water-soluble form of the potent MAP kinase inhibitor SB 203580 with IC50 values of 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. It was shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Synonyms: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole hydrochloride. Grades: >98%. CAS No. 869185-85-3. Molecular formula: C21H17FN3OSCl. Mole weight: 413.9. |  |
| SB 203580, Hydrochloride - CAS 869185-85-3 | SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC?? = 34 nM in vitro, 600 nM in cells). Group: Fluorescence/luminescence spectroscopy. | |
| SB 203580 Hydrochloride Salt | SB 203580 Hydrochloride Salt. Group: Biochemicals. Alternative Names: 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; hydrochloride; SB203580 hydrochloride; SCHEMBL4890447; HY-10256A. Grades: Highly Purified. CAS No. 869185-85-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C21 H16 FN 3 , Molecular Weight: 413.9. US Biological Life Sciences. |  Worldwide |
| InSolution SB 203580 | InSolution SB 203580, CAS 152121-47-6, is a 1 mg/ml solution of SB 203580 in DMSO. A cell-permeable, selective, reversible inhibitor of p38 MAP kinase (IC?? = 34 nM in vitro, 600 nM in cells). Group: Fluorescence/luminescence spectroscopy. | |
| SB-203580 | SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM. Uses: Enzyme inhibitors. Synonyms: SB203580; SB203580; SB 203580. Grades: >98%. CAS No. 152121-47-6. Molecular formula: C21H16FN3OS. Mole weight: 377.437. | |
| p38 MAP Kinase Inhibitor XIX, Skepinone-L ((2-(2,4-Difluorophenylamino)-7-[2R-,3-dihydroxypropoxy]-10,11-dihydro-dibenzo[a,d]-cyclohepten-5-one)) | A cell-permeable phenylamino-dibenzosuberone-diol with a rigid molecular structure specifically designed to target hydrophobic region I in p38alpha & p38beta, but not in other kinases with bulky entrance-blocking gatekeeper residues. Shown to selectively inhibit p38alpha (IC50 = 5nM; [ATP] = 100uM) and p38beta (97% inhibition at 1uM), while exhibiting little affinity toward 400 other kinase constructs, including p38delta, p38upsilon, Erk1/2/3/4/5/8, JNK1/2/3, and MEK1/2/3/4/6. Shown to prevent cellular HSP27 Ser82 phosphorylation upon p38 activation by Anisomycin in HeLa (IC50 = 25nM) or by TNF-alpha in THP-1 cultures. Unlike the ATP-binding site-targeting BIRB 796 and SB 203580, Skepinone-L does not inhibit JNK-mediated c-Jun or ERK-dependent CREB phosphorylation in THP-1 cultures. Oral administration to D-Gal-sensitized mice is reported to greatly reduce plasma TNF-alpha production upon LPS challenge (by 77%; 3mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| SB 202474 | SB 202474 is an analog of SB 202190 and SB 203580, which are inhibitors of the MAP kinases p38α and p38&beta. SB 202474 has been used as a negative control in studies of p38 inhibition. Synonyms: SB-202474; SB202474; 4-[5-ethyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl]pyridine. Grades: ≥97%. CAS No. 172747-50-1. Molecular formula: C17H17N3O. Mole weight: 279.3. | |
| TA-02 | TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC 50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1784751-19-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100115. |  |
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