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| Product | Description | |
|---|---|---|
| SB 612111 | SB 612111 hydrochloride is a selective nociceptin/orphanin FQ (NOP) receptor antagonist (Ki value 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). It modulates the pronociceptive action of nociceptin in an acute pain model and enhances morphine action in morphine-tolerant animals and inhibits hyperalgesia in an inflammatory pain model. Synonyms: SB 612111 hydrochloride; SB612111 hydrochloride; SB-612111 hydrochloride; (5S,7S)-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol hydrochloride. Grades: 99%. CAS No. 371980-98-2. Molecular formula: C24H29Cl2NO. Mole weight: 418.4. |  |
| SB 612111 hydrochloride | SB 612111 hydrochloride. CAS No: 371980-98-2 |  Sarchem Laboratories New Jersey NJ |
| SB 612111 hydrochloride | SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki = 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors, respectively). SB 612111 exhibits antagonist activity at the pronociceptive action of nociceptin in an acute pain model. SB 612111 potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model. Synonyms: SB 612111 hydrochloride; SB612111 hydrochloride; SB-612111 hydrochloride; 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride. Grades: ≥97% by HPLC. CAS No. 371980-94-8. Molecular formula: C24H29Cl2NO.HCl. Mole weight: 454.86. | |
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