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| Product | Description | |
|---|---|---|
| Sb-277011 | Sb-277011 is a novel, high-anity and selective dopamine D3 receptor antagonist that may have potential in treating the negative symptoms of schizophrenia. pKi: 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively. Synonyms: N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide SB 277011 SB 277011-A SB-277011 SB-277011-A trans-N-(4-(2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)cyclohexyl)-4-quinolinecarboxamide. CAS No. 215803-78-4. Molecular formula: C28H30N4O. Mole weight: 438.56. |  |
| SB-277011-A Dihydrochloride (SB277011A, SB 277011A, Dopamine D3 Receptor Antagonist, SB-277011-A, SB-277011A) | A brain-penetrant, high-affinity, and selective dopamine D3 receptor antagonist. High affinity for the hD3 receptor (pKi = 7.95) with 100-fold selectivity over the hD2 receptor and over 66 other receptors, enzymes, and ion channels. Rat data shows that the compound is selective for the D3 receptor over certain serotonergic and cholinergic receptors at doses up to 56mg/kg and strong physiological response at 32mg/kg. Group: Biochemicals. Grades: Highly Purified. CAS No. 1226917-67-4. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| SB-277011-A hydrochloride hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SB-277011 hydrochloride | SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D 3 receptor (D 3 R) antagonist with K i values of 10.7 nM and 11.2 nM at rodent and human D 3 R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK i s of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT 1B , and 5-HT 1D receptors, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-277011A hydrochloride. CAS No. 215804-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10847B. |  |
| Sb 277011 hydrochloride | Sb 277011 hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SB 277011 Hydrochloride;N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]- 4-quinolinecarboxaMide Hydrochloride;SB 277011A Hydrochloride;SB 277211 Hydrochloride;SB-277011-A hydrochloride hydrate. CAS No. 215804-67-4. Molecular formula: C28H30N4O. Mole weight: 438.564. Purity: 98%+. IUPACName: N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide. Canonical SMILES: C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45. Product ID: ACM215804674. Alfa Chemistry ISO 9001:2015 Certified. |  |
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