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| Product | Description | |
|---|---|---|
| SC-9 | SC-9. Group: Biochemicals. Grades: Purified. CAS No. 102649-78-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| SC-9 | SC-9 is a potent activator of protein kinase C in the presence of Ca2+. Synonyms: SC-9; SC 9; SC9; 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide. Grades: ≥99% by HPLC. CAS No. 102649-78-5. Molecular formula: C22H24ClNO2S. Mole weight: 401.95. |  |
| Protein Kinase Activator SC-9 (N- (6-phenylhexyl) -5-chloro-1-naphthalene sulfonamide) | Activates protein kinase C in a Ca2+-dependent manner, via a mechanism similar to that of phosphatidylserine. Group: Biochemicals. Alternative Names: N- (6-phenylhexyl) -5-chloro-1-naphthalene sulfonamide. Grades: Molecular Biology Grade. CAS No. 102649-78-5. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| Spironolactone-d3 ((7a,7a)-7-(Acetylthyo-d3)-17-hydroxy-3-oxopregn-4-one-21-carboxylic Acid g-Lactone,. 7a-Acetylthio-d3-3-oxo-17a-pregn-4-ene-21,17-carbolactone, SC-9420-d3) | t is a synthetic 17-lac. Group: Biochemicals. Alternative Names: (7a,7a)-7-(Acetylthyo-d3)-17-hydroxy-3-oxopregn-4-one-21-carboxylic Acid g-Lactone; 7a-Acetylthio-d3-3-oxo-17a-pregn-4-ene-21,17-carbolactone; SC-9420-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 1-[(6-Chloropyridin-3-yl)methyl]-4-methylpiperazine | 1-[(6-Chloropyridin-3-yl)methyl]-4-methylpiperazine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-[(6-chloropyridin-3-yl)methyl]-4-methylpiperazine, 612487-31-7, 1-[(6-chloro-3-pyridinyl)methyl]-4-methylpiperazine, AC1LSYLX, CTK6I3196, MolPort-002-858-189, BB_SC-9533, STL377980, AKOS000160024, MCULE-6027860824, KB-216810, FT-0684409, I13-472. Product Category: Heterocyclic Organic Compound. CAS No. 612487-31-7. Molecular formula: C11H16ClN3. Mole weight: 225.72. Purity: 0.96. IUPACName: 1-[(6-chloropyridin-3-yl)methyl]-4-methylpiperazine. Canonical SMILES: CN1CCN(CC1)CC2=CN=C(C=C2)Cl. Product ID: ACM612487317. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2,4,6-Tri(4-pyridyl)-1,3,5-triazine (purified by sublimation) | 2,4,6-Tri(4-pyridyl)-1,3,5-triazine (purified by sublimation). Uses: 2,4,6-tri(4-pyridyl)-1,3,5-triazine is used in the preparation of metal-metallite coordination polymers as well as porphyrin prisms. Group: other material building blockssemiconductor blocks. Alternative Names: 2,4,6-Tri(4-pyridinyl)-1,3,5-triazine; AM808280; SC-95201; CBMYFVSIIYILRH-UHFFFAOYSA-N; FT-0606529; CJ-29874; DTXSID30195150; ML01052; I14-108432; AC1L7WH6. CAS No. 42333-78-8. Product ID: 2,4,6-tripyridin-4-yl-1,3,5-triazine. Molecular formula: 312.34. Mole weight: C18H12N6. C1=CN=CC=C1C2=NC (=NC (=N2)C3=CC=NC=C3)C4=CC=NC=C4. InChI=1S/C18H12N6/c1-7-19-8-2-13 (1)16-22-17 (14-3-9-20-10-4-14)24-18 (23-16)15-5-11-21-12-6-15/h1-12H. CBMYFVSIIYILRH-UHFFFAOYSA-N. >97.0%(N). |  |
| 3-(3-Amino-1H-1,2,4-triazol-5-yl)propanoic acid | 3-(3-Amino-1H-1,2,4-triazol-5-yl)propanoic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(5-amino-1H-1,2,4-triazol-3-yl)propanoic acid, 933753-12-9, 3-(5-amino-4H-1,2,4-triazol-3-yl)propanoic acid, CTK5H2421, MolPort-008-420-807, BB_SC-8493, BB_SC-9539, BBL013126, SBB026523, STK353449, AKOS002657050, AKOS005168876, AKOS005174526, AG-H-81682, MCULE-5581856354, AK107423, FT-0683937, ST45146334, ST50689948, 3-(5-amino-2H-1,2,4-triazol-3-yl)propanoic acid. Product Category: Heterocyclic Organic Compound. CAS No. 933753-12-9. Molecular formula: C5H8N4O2. Mole weight: 156.15. Purity: 0.96. IUPACName: 3-(3-amino-1H-1,2,4-triazol-5-yl)propanoic acid. Density: 1.554g/cm³. Product ID: ACM933753129. Alfa Chemistry ISO 9001:2015 Certified. | |
| 3-Chloro-5-(trifluoromethyl)-1H-1,2,4-triazole | 3-Chloro-5-(trifluoromethyl)-1H-1,2,4-triazole. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-chloro-5-(trifluoromethyl)-1H-1,2,4-triazole, 1199215-88-7, Ambcb4019882, MolPort-008-154-159, BB_SC-9171, BBL011558, STL146694, ZINC40457289, AKOS005173665, AKOS006333542, MCULE-7126363159, KB-245622, FT-0683571, 5-chloro-3-(trifluoromethyl)-1h-1,2,4-triazole, I14-28577. Product Category: Heterocyclic Organic Compound. CAS No. 1199215-88-7. Molecular formula: C3HClF3N3. Mole weight: 171.51. Purity: 0.96. IUPACName: 3-chloro-5-(trifluoromethyl)-1H-1,2,4-triazole. Canonical SMILES: C1(=NC(=NN1)Cl)C(F)(F)F. Product ID: ACM1199215887. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-[(6-Chloropyridin-3-yl)methyl]morpholine | 4-[(6-Chloropyridin-3-yl)methyl]morpholine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-[(6-chloropyridin-3-yl)methyl]morpholine, 4-[(6-chloro-3-pyridinyl)methyl]morpholine, 311774-34-2, 4-((6-Chloropyridin-3-yl)methyl)morpholine, Bionet2_001631, AC1MU7OT, AC1Q3KTK, CTK6H1442, MolPort-002-858-190, BB_SC-9084, HMS1368M03, ALBB-008883, BBL012521, STK501621, ZINC19283156, AKOS000154837, AG-A-69811, MCULE-3566387977, AK125486, ST069057. Product Category: Heterocyclic Organic Compound. CAS No. 311774-34-2. Molecular formula: C10H13ClN2O. Mole weight: 212.68. Purity: 0.96. IUPACName: 4-[(6-chloropyridin-3-yl)methyl]morpholine. Canonical SMILES: C1COCCN1CC2=CN=C(C=C2)Cl. Product ID: ACM311774342. Alfa Chemistry ISO 9001:2015 Certified. | |
| 4-Bromo-2,6-difluorobenzoyl chloride | 4-Bromo-2,6-difluorobenzoyl chloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-bromo-2,6-difluorobenzoyl chloride, 497181-19-8, Benzoyl chloride, 4-bromo-2,6-difluoro-, ZINC02506844, AC1MCMQW, SCHEMBL1085223, CTK1C6828, DTXSID00378352, ZINC2506844, MFCD03094086, PC0738, SBB101623, AKOS023118474, AK178231, KB-85717, OR169857, SC-90264, A3621, FT-0698478, Q-8568. Product Category: Aryl Fluorinated Building Blocks. CAS No. 497181-19-8. Molecular formula: C7H2BrClF2O. Mole weight: 255.44. Purity: 0.96. IUPACName: 4-bromo-2,6-difluorobenzoyl chloride. Canonical SMILES: C1=C(C=C(C(=C1F)C(=O)Cl)F)Br. Product ID: ACM497181198. Alfa Chemistry ISO 9001:2015 Certified. | |
| 5-(3-Fluoro-phenyl)-2H-pyrazol-3-ylamine | 5-(3-Fluoro-phenyl)-2H-pyrazol-3-ylamine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(3-fluorophenyl)-1H-pyrazol-5-amine, 766519-89-5, 5-(3-fluorophenyl)-1H-pyrazol-3-amine, AG-H-06043, 1H-Pyrazol-3-amine, 5-(3-fluorophenyl)-, 3-AMINO-5-(3-FLUOROPHENYL)-1H-PYRAZOLE, 1028842-99-0, PubChem12134, AGN-PC-01XEFB, SureCN168536, Ambcb4010171, SureCN1853364, CTK2H5898, CTK4A1579, MolPort-002-015-895, BB_SC-9485, STL163426, ZINC13483213, AKOS000111382, AKOS000194405. Product Category: Heterocyclic Organic Compound. CAS No. 766519-89-5. Molecular formula: C9H8FN3. Mole weight: 177.1807. Purity: 97+%. IUPACName: 5-(3-fluorophenyl)-1H-pyrazol-3-amine. Canonical SMILES: C1=CC(=CC(=C1)F)C2=CC(=NN2)N. Density: 1.334g/cm³. Product ID: ACM766519895. Alfa Chemistry ISO 9001:2015 Certified. | |
| Bis(3,5,3',5'-dimethoxydibenzylideneacetone)palladium(0) | Bis(3,5,3',5'-dimethoxydibenzylideneacetone)palladium(0). Uses: Suzuki reaction. Additional or Alternative Names: bis(3 5 3' 5'-dimethoxydibenzylideneace&; Bis(3,5,3',5 -dimethoxydibenzylideneacetone)palladium(0); bis(3,5,3',5'-dimethoxydibenzylideneacetone)palladium; BIS(3 5 3' 5'-DIMETHOXYDIBENZYLIDENEACE; bis(3,5,3',5'-dimethoxydibenzylideneacetone)palladium(0), pd 13%; 811862-77-8; SC-90668; Bis(3,5,3',5 inverted exclamation marka-dimethoxydibenzylideneacetone)palladium(0); Bis(3,5,3',5'-dimethoxydibenzylideneacetone)palladium(0); DTXSID10584705. Product Category: Palladium series catalysts. CAS No. 811862-77-8. Molecular formula: C42H44O10Pd. Mole weight: 815.224g/mol. IUPACName: (1E,4E)-1,5-bis(3,5-dimethoxyphenyl)penta-1,4-dien-3-one;palladium. Canonical SMILES: COC1=CC(=CC(=C1)C=CC(=O)C=CC2=CC(=CC(=C2)OC)OC)OC.COC1=CC(=CC(=C1)C=CC(=O)C=CC2=CC(=CC(=C2)OC)OC)OC.[Pd]. Product ID: ACM811862778. Alfa Chemistry ISO 9001:2015 Certified. | |
| EXO-N-HYDROXY-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXIMIDE | EXO-N-HYDROXY-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXIMIDE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: exo-N-Hydroxy-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide, (4R,7S)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione, Oprea1_653889, MolPort-002-549-470, BB_SC-9417, 5596-17-8, STK526778, AKOS005460257, MCULE-5147862309, FT-0080384, FT-0650865. Product Category: Heterocyclic Organic Compound. CAS No. 5596-17-8. Molecular formula: C8H7NO4. Mole weight: 181.15. Purity: 0.96. IUPACName: (4R,7S)-2-hydroxy-3a,4,7,7a-tetrahydro-octahydro-1H-4,7-epoxyisoindole-1,3-dione. Canonical SMILES: C1=CC2C3C(C1O2)C(=O)N(C3=O)O. Density: 1.728g/cm³. Product ID: ACM5596178. Alfa Chemistry ISO 9001:2015 Certified. | |
| Fluorogestone acetate | Fluorogestone Acetate (also known as Flurogestone Acetate, Flugestone Acetate, Fluorogesterone Acetate) was first synthesised by G. D. Searle and Company in 1959. The chemical, which has progestogen activity, was identified as SC-9880. Fluorogestone acetate showed a high potency with short duration of activity and performed physiologically similar to progesterone. FGA was approximately 20 - 25 times more potent than progesterone. Flurogestone acetate was shown to be readily absorbed from impregnated sponges. A 30mg impregnated sponge was effective in blocking ovulation and oestrus, once the sponge was removed impregnated ewes showed visible oestrus, and if inseminated 2 to 4 days after sponge removal showed high conception rates. Synonyms: Flugestone 17-acetate; Flugestone Acetate; 9-Fluoro-11beta,17-dihydroxypregn-4-ene-3,20-dione 17-acetate; NSC 65411; (11beta)17-(Acetyloxy)-9-fluoro-11-hydroxypregn-4-ene-3,20-dione. Grades: 98%. CAS No. 2529-45-5. Molecular formula: C23H31FO5. Mole weight: 406.49. | |
| N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide | N- (6-Phenylhexyl) -5-chloro-1-naphthalene sulfonamide. Group: Biochemicals. Alternative Names: 5-Chloro-N- (6-phenylhexyl) -1-naphthalene sulfonamide; SC-9. Grades: Highly Purified. CAS No. 102649-78-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C22H24ClNO2S. US Biological Life Sciences. | Worldwide |
| Pracinostat | Pracinostat (SB939) is an orally bioavailable, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. This agent may possess improved metabolic, pharmacokinetic and pharmacological properties compared to other HDAC inhibitors. Synonyms: SB939; SB 939; SB-939; SC-939; SC 939; SC939; Pracinostat. Grades: >98%. CAS No. 929016-96-6. Molecular formula: C20H30N4O2. Mole weight: 358.486. | |
| Spironolactone | Spironolactone is a synthetic, 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Alternative Names: 7α,7α)-7-(Acetylthyo)-17-hydroxy-3-oxopregn-4-one-21-carboxylic Acid γ-Lactone; 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17-carbolactone; SC-9420; Adactone. Grades: Highly Purified. CAS No. 52-01-7. Pack Sizes: 50g, 100g. Molecular Formula: C??H??O?S, Molecular Weight: 416.57. US Biological Life Sciences. | Worldwide |
| Tris(2-carboxyethyl)phosphine Hydrochloride | Tris(2-carboxyethyl)phosphine Hydrochloride. Uses: Biochemical tool for selective reduction of disulfide bridges at low ph; reductant for redox assays. Additional or Alternative Names: Tris(2-carboxyethyl)phosphine hydrochloride, 0.5M solution in water; Tris(2-carboxyethyl)phosphine hydrochloride solution, 0.5 M, pH 7.0(aqueous solution; PBVAJRFEEOIAGW-UHFFFAOYSA-N; Tris(2-carboxyethyl)phosphine hydrochloride, powder, >=98%; FT-0657850; AB0031602; Tris(2-carboxyethyl)phosphine, HCl; ACMC-209kw4; X4741; SC-90729. CAS No. 51805-45-9. Molecular formula: C6H12Cl3O4P;C9H16ClO6P. Mole weight: 286.645g/mol. IUPACName: 3-[bis(2-carboxyethyl)phosphanyl]propanoic acid;hydrochloride. Canonical SMILES: C(CP(CCC(=O)O)CCC(=O)O)C(=O)O.Cl. Density: Relative density (water = 1): 1.4. Product ID: ACM51805459. Alfa Chemistry ISO 9001:2015 Certified. Categories: Tris-2-carboxyethylphosphine hydrochloride. | |
| Verteporfin | Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin. It is used as a photosensitizer for photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. Verteporfin also suppresses the formation of autophagosome via targeting p62, which binds both polyubiquitinated proteins destined for degradation and LC3 on autophagosomal membranes. Synonyms: CL 318952; SC 95659; CL318952; SC95659; CL-318952; SC-95659; BPD-MA-A1; (4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid, monomethyl ester. Grades: 95%. CAS No. 129497-78-5. Molecular formula: C41H42N4O8. Mole weight: 718.81. | |
| Cefotiam hydrochloride | Cefotiam (SCE-963) hydrochloride is a parenteral cephalosporin antibiotic. Cefotiam hydrochloride has broad-spectrum activity against Gram-positive and Gram-negative bacteria [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCE-963 hydrochloride. CAS No. 66309-69-1. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-B0734A. |  |
| Gentamicin Sulfate | Gentamycin Sulfate is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms. Uses: Broad-spectrum, aminoglycoside antibiotic. Synonyms: Gentamicin C; NSC-82261; NSC82261; NSC 82261; SCH9724; SCH 9724; SCH-9724; Alcomicin; Bristagen; Cidomycin; Duragentam; Garamycin; Garasol; Genoptic; Gentacidin; Gentacin; Gentaglyde; Gentalyn; Gentamicin C Complex Citrate; Gentibioptal; Genticin; Gentocin; Gentogram; Gent-Ophtal; Getalline; GM Sulfate. Grades: Assay: ≥ 590 I.U./mg. CAS No. 1405-41-0. Molecular formula: C(19-21)H(39-43)N5O7.H2SO4. Mole weight: 561.65 (Average). | |
| Gentamicinsulfate salt | Gentamicinsulfate salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GENTAMYCINE; Gentavet; GentamysinsolutionforBiochemistry; GENTAMYCIN; Gentacycol; Lyramycin; Uromycine; Refobacin tm; GENTAMICINUM. Appearance: clear amber liquid. CAS No. 1403-66-3. Molecular formula: C21H43N5O7. Mole weight: 477.6. Purity: 0.95. IUPACName: Gentamicin. Density: 1.3 g/cm³. Product ID: ACM1403663. Alfa Chemistry ISO 9001:2015 Certified. Categories: SCH-9724. | |
| Narlaprevir | Narlaprevir is a potent, selective, orally bioavailable inhibitor of the hepatitis C virus (HCV) nonstructural protein 3 serine protease that is primarily metabolized by the cytochrome P450-3A4 system. Synonyms: SCH-900518; SCH 900518; SCH900518; Narlaprevir. Grades: >98%. CAS No. 865466-24-6. Molecular formula: C36H61N5O7S. Mole weight: 707.96. | |
| ORG 25935 hydrochloride | ORG 25935 hydrochloride is a potent and selective glycine transporter 1 (GlyT-1) or reuptake inhibitor intended for the treatment of neurological disorders such as schizophrenia. Uses: Treatment of neurological disorders. Synonyms: SCH-900435; SCH 900435; SCH900435; ORG 25935 hydrochloride; ORG25935 hydrochloride; ORG-25935 hydrochloride; rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride. Grades: 99%. CAS No. 949588-40-3. Molecular formula: C21H25NO3.HCl. Mole weight: 375.89. | |
| pembrolizumab | Pembrolizumab (formerly MK-3475 and lambrolizumab, trade name Keytruda) is a humanized antibody used in cancer immunotherapy. It targets the programmed cell death 1 (PD-1) receptor. The drug was initially used in treating metastatic melanoma. Synonyms: Anti-PD-1 monoclonal antibody - Merck; Humanised monoclonal IgG4 antibody against PD-1 - Merck; Keytruda; Lambrolizumab; MK-3475; MK 3475; MK3475; SCH-900475; SCH 900475; SCH900475. CAS No. 1374853-91-4. | |
| SCH-900271 | SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC 50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 915210-50-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-111143. | |
| SCH900776 | SCH900776, also known as MK-8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest. Synonyms: SCH-900776; SCH 900776, MK-8776; MK 8776; MK8776. Grades: >98%. CAS No. 891494-63-6. Molecular formula: C15H18BrN7. Mole weight: 376.262. | |
| SCH900776 S-isomer | SCH900776 S-isomer is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1. It can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. It enhances the γ-H2AX response of hydroxyurea, 5-fluoruracil, and cytarabine. It suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner. Uses: Sch900776 s-isomer can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. Synonyms: SCH900776 S-isomer; SCH 900776 S-isomer; SCH-900776 S-isomer; (S)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-A]pyrimidin-7-amine;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((3S)-piperidin-3-yl)pyrazolo(1,5-a)pyrimidin-7-amine;SCH-900776 S-isomer. Grades: >98%. CAS No. 891494-64-7. Molecular formula: C15H18BrN7. Mole weight: 376.25. | |
| Verubecestat | Verubecestat, an iminothiadiazine dioxide compound, is an oral BACE1 inhibitor originated by Merck & Co. It can bind significantly to β-secretase. Verubecestat has the potent effect to treat Alzheimer's disease and is currently in Phase III clinical trials. Uses: Alzheimer's disease. Synonyms: N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide; J1I0P6WT7T; Verubecestat; UNII-J1I0P6WT7T; J1I0P6WT7T; 1286770-55-5; Verubecestat [USAN]; Verubecestat (USAN/INN); GTPL8699; CHEMBL3301601; SCHEMBL10328722; SCHEMBL17507398; BDBM143220; example 25 (US8940748); SCH-900931; D10739; US8940748, 25; 2-Pyridinecarboxamide, N-(3-((5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoro-; N-(3-((5R)-3-amino-2,5-dimethyl-1,1-dioxo-1,2,5,6-tetrahydro-1lambda6,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropyridine-2-carboxamide; N-(3-((5R)-3-amino-2,5-dimethyl-1,1-dioxo-5,6-dihydro-2H-1lambda6,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropyridine-2-carboxamide; N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide. Grades: 98%. CAS No. 1286770-55-5. Molecular formula: C17H17F2N5O3S. Mole weight: 409.41. | |
| Verubecestat TFA | Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MK-8931; MK 8931; MK8931; MK-8931-009; SCH 900931; SCH-900931; SCH900931; Verubecestat TFA. Product Category: Inhibitors. Appearance: White to off-white solid powder. CAS No. 2095432-65-6. Molecular formula: C19H18F5N5O5S. Mole weight: 523.44. Purity: >98%. IUPACName: (R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide trifluoroacetic acid. Canonical SMILES: O=C(NC1=CC=C(F)C([C@@](C2)(C)N=C(N)N(C)S2(=O)=O)=C1)C3=NC=C(F)C=C3.O=C(O)C(F)(F)F. Product ID: ACM2095432656. Alfa Chemistry ISO 9001:2015 Certified. | |
| ZM323881 | ZM323881 inhibits VEGF-A, EGF and bFEF induced HUVEC cell proliferation with IC50 of 8 nM, 1.9 μM and 1.6 μM, respectively. ZM323881 (10 nM) abolishes VEGF-A-mediated increases in vascular permeability in perfused mesenteric microvessels in male leopard. ZM323881 (10 nM) blocks the increase in intensity of the VEGF-R2 band in the lung of male leopard frogs. M323881 (1 μM) blocks activation of extracellular regulated-kinase, p38, Akt, and endothelial nitric oxide synthetase (eNOS) by VEGF, but did not inhibit p38 activation by the VEGFR-1-specific ligand, placental growth factor (PIGF) in human aortic endothelial cells (HAECs). ZM323881 (1 μM) also perturbes VEGF-induced membrane extension, cell migration, and tube formation by HAECs. ZM323881 (1 μM) reverses VEGF-stimulated phosphorylation of CrkII and its Src homology 2 (SH2)-binding protein p130Cas, which are known to play a pivotal role in regulating endothelial cell migration. ZM323881 (10 nM) completely blocks VEGF-induced VEGF promoter activity in SCC-9 cells. ZM323881 (10 nM) blocks VEGF stimulated Hif-1α protein accumulation in SCC-9 cells. ZM323881 (10 nM) blocks VEGF-induced Rac1 activation at 30 min in HUVECs. ZM323881 (10 nM) prevents Vav2 tyrosine phosphorylation in response to VEGF in HUVECs. Synonyms: ZM 323881; ZM-323881. Grades: >98%. CAS No. 193001-14-8. Molecular formula: C22H18FN3O2. Mole weight: 375.4. | |
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