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| Product | Description | |
|---|---|---|
| SC79 | ?97% (NMR). Group: Fluorescence/luminescence spectroscopy. |  |
| SC79 | SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation. Synonyms: SC-79; SC 79; SC79. Grades: 98%. CAS No. 305834-79-1. Molecular formula: C17H17ClN2O5. Mole weight: 364.78. |  |
| Akt Activator II, SC79 (Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) | A cell-permeable and blood-brain barrier permeant HA14-1 analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4ug/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4ug/ml) in vitro and in a murine MCAO model (40mg/kg, i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 305834-79-1. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. |  Worldwide |
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