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| Product | Description | |
|---|---|---|
| SCH900776 | SCH900776, also known as MK-8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest. Synonyms: SCH-900776; SCH 900776, MK-8776; MK 8776; MK8776. Grades: >98%. CAS No. 891494-63-6. Molecular formula: C15H18BrN7. Mole weight: 376.262. |  |
| SCH900776 S-isomer | SCH900776 S-isomer is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1. It can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. It enhances the γ-H2AX response of hydroxyurea, 5-fluoruracil, and cytarabine. It suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner. Uses: Sch900776 s-isomer can be used as a protein kinase inhibitor useful in the treatment of protein kinase-mediated diseases. Synonyms: SCH900776 S-isomer; SCH 900776 S-isomer; SCH-900776 S-isomer; (S)-6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-A]pyrimidin-7-amine;6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-((3S)-piperidin-3-yl)pyrazolo(1,5-a)pyrimidin-7-amine;SCH-900776 S-isomer. Grades: >98%. CAS No. 891494-64-7. Molecular formula: C15H18BrN7. Mole weight: 376.25. | |
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