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| Product | Description | |
|---|---|---|
| Selumetinib | Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. Synonyms: ARRY-142886; ARRY 142886; ARRY142886; AZD6244; AZD-6244; AZD 6244; ARRY-886; ARRY886; ARRY 886. Grades: >98%. CAS No. 606143-52-6. Molecular formula: C17H15BrClFN4O3. Mole weight: 457.684. |  |
| Selumetinib | Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC 50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD6244; ARRY-142886. CAS No. 606143-52-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50706. |  |
| Selumetinib | Selumetinib. Group: Biochemicals. Alternative Names: 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; ARRY 142886; AZD 6244. Grades: Highly Purified. CAS No. 606143-52-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C17H15BrClFN4O3. US Biological Life Sciences. |  Worldwide |
| Selumetinib sulfate | Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC 50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD6244 sulfate; ARRY-142886 sulfate. CAS No. 943332-08-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50706A. | |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Synonyms: AZD-0364; AZD 0364; tizaterkib. Grades: ≥98%. CAS No. 2097416-76-5. Molecular formula: C24H24F2N8O2. Mole weight: 494.50. | |
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