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| Product | Description | |
|---|---|---|
| Semagacestat | Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid ( Aβ42 ), Aβ38 and Aβ40 with IC 50 s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC 50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY450139. CAS No. 425386-60-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10009. |  |
| Semagacestat | Semagacestat is an inhibitor of the γ-secretase complex that blocks the production of Aβ38 (IC50= 12.0 nM), Aβ40 (IC50= 12.1 nM), and Aβ42 (IC50= 10.9 nM) from H4 human glioma cells stably overexpressing human wild-type APP into the culture medium. In vitro: blocks the production of Aβ38 (IC50= 12.0 nM), Aβ40 (IC50= 12.1 nM), and Aβ42 (IC50= 10.9 nM) without affecting cell viability. In vivo: decreases hippocampal levels of both Aβ42 and Aβ40 at 10 mg/kg (22-23% reduction) and 30 mg/kg (36-41% reduction) and increases β-CTF at 0.3-10 mg/kg in a dose dependent manner with no inhibition on the processing of other γ-secretase substrates, such as Notch, N-cadherin or EphA4, in the brain, but impairs normal cognition in wild-type mice and 3-month-old Tg2576 mice failing to restore cognitive deficits in the Y-maze test. Uses: Gamma secretase inhibitors and modulators. Synonyms: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide; LY 411,575; LY 411575; LY 450139; LY-411,575; LY-411575; LY411,575; LY411575; LY450139; N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide; LY4501; LY-4501; LY 4501; LY450139; LY-450139; LY 450139; Semagacestat. 425386-60-3. Grades: >98%. CAS No. 425386-60-3. Molecular formula: C19H27N3O4. Mole weight: 361.44. |  |
| Semagacestat | Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (A β), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD). Group: Biochemicals. Alternative Names: (2S) -2-Hydroxy-3-methyl-N- [ (1S) -1-methyl-2-oxo-2- [ [ (1S) -2, 3, 4, 5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl] amino] ethyl] butanamide; LY 450139. Grades: Highly Purified. CAS No. 425386-60-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| LY-411575 (LY 411575, LY411575, Semagacestat) | LY-411575 (LY 411575, LY411575, Semagacestat). Group: Biochemicals. Alternative Names: (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide. Grades: Highly Purified. CAS No. 209984-57-6. Pack Sizes: 25mg. Molecular Formula: C26H23F2N3O4, Molecular Weight: 479.5. US Biological Life Sciences. | Worldwide |
| LY-411575 | LY-411575, also known as LSN-411575, is a potent, cell-permeable γ-secretase inhibitor (IC50 = 0.078 nM/0.082 nM in membrane-assay/in cell-basedγ-secretase assays) and also inhibits Notch clevage (IC50 = 0.39 nM). Synonyms: LY 411575; LY-411575; LY411575; LSN-411575; LSN 411575; LSN411575. (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide; LY 411,575; LY 411575; LY 450139; LY-411,575; LY-411575; LY411,575; LY411575; LY450139; N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; N2-(2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)alaninamide; Semagacestat; 209984-57-6. Grades: >98%. CAS No. 209984-57-6. Molecular formula: C26H23F2N3O4. Mole weight: 479.48. | |
| LY 450139 | Semagacestat is a gamma-secretase inhibitor originally developed by Eli Lilly. In Aug 2010, Phase-III for Alzheimer's disease was discontinued. Uses: Alzheimer's disease. Synonyms: LY 450139; LY450139; LY-450139. (S)-2-hydroxy-3-methyl-N-((S)-1-(((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)amino)-1-oxopropan-2-yl)butanamide. Grades: 98%. CAS No. 866488-53-1. Molecular formula: C19-H27-N3-O4. Mole weight: 361.44. | |
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