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| Product | Description | |
|---|---|---|
| SGC0946 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SGC0946 | SGC0946 Inhibitor. Uses: Scientific use. Product Category: T3082. CAS No. 1561178-17-3. |  |
| SGC0946 | SGC0946 is a selective DOT1L H3K79 methyltransferase ) inhibitor, with an IC 50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1561178-17-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15650. |  |
| SGC 0946 | SGC0946 is a potent and selective inhibitor of DOT1L, which potently and selectively kills cells containing an MLL translocation. SGC0946 inhibits DOT1L with an IC50 of 0.3nM in a radioactive enzyme assay and is over 100-fold selective for other HMTs. Synonyms: SGC-0946; SGC 0946; SGC0946. Grades: >98%. CAS No. 1561178-17-3. Molecular formula: C28H40BrN7O4. Mole weight: 618.57. |  |
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