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| Product | Description | |
|---|---|---|
| SGI 1027 | SGI 1027. Group: Biochemicals. Grades: Purified. CAS No. 1020149-73-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| SGI 1027 dihydrochloride | SGI 1027 is a DNA methyltransferase (DNMT) inhibitor (IC50 values 35 μM and 10 μM for DNMT1 and DNMT3A2/3L, respectively). It was shown to degrade the enzymes and reactivate the silenced tumor suppressor genes (TSGs) P16, MLH1, and TIMP3 devoid of significant toxicity in a rat hepatoma (H4IIE) cell line. Synonyms: SGI 1027 dihydrochloride; SGI1027 dihydrochloride; SGI-1027 dihydrochloride; N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide dihydrochloride. Grades: 99%. CAS No. 2108487-01-8. Molecular formula: C27H25Cl2N7O. Mole weight: 534.44. |  |
| SGI-1027 | SGI-1027 is a potent DNMT inhibitor, which reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Treatment of different cancer cell lines with SGI-1027 resulted in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B. SGI-1027 may have the potential for use in epigenetic cancer therapy. Synonyms: SGI 1027; SGI1027. Grades: 0.98. CAS No. 1020149-73-8. Molecular formula: C27H23N7O. Mole weight: 461.529. | |
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