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| Product | Description | |
|---|---|---|
| SHP099 | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo. Synonyms: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine; SHP099; SHP-099; SHP 099. CAS No. 1801747-42-1. Molecular formula: C16H19Cl2N5. Mole weight: 352.26. |  |
| SHP099 dihydrochloride | SHP099 is a potent and small-molecule inhibitor that has selectivity for SHP2 over SHP1 (IC50?=?0.071?μM), which is orally bioavailable. In xenograft models, SHP099 exhibited an inhibitory effect on dose-dependent pathway and antineoplastic activity. It also plays a role in the programmed cell death pathway (PD-1/PD-L1). Synonyms: SHP099 dihydrochloride; SHP 099 dihydrochloride; SHP-099 dihydrochloride; KS-00000TTA; AKOS030632792; 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride. Grades: 99.70 %. Molecular formula: C16H21Cl4N5. Mole weight: 425.18. | |
| SHP099 HCl | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo. Synonyms: 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride; SHP099; SHP-099; SHP 099. SHP-099 hydrochloride, SHP-099 HCl. CAS No. 1801747-11-4. Molecular formula: C16H20Cl3N5. Mole weight: 388.72. | |
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