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| Product | Description | |
|---|---|---|
| SKL2001 free base | SKL-2001 is a novel agonist of Wnt/β-catenin signaling pathway. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. SKL2001 inhibited proliferation of colon cancer cells cultured in 3D spheroid and induced them accumulation in the G0/G1 phase of the cell cycle with a reduced c-myc level. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SKL-2001; SKL 2001; SKL2001; Wnt Agonist II. Product Category: Agonists. Appearance: Solid powder. CAS No. 909089-13-0. Molecular formula: C14H14N4O3. Mole weight: 286.29. Purity: >98%. IUPACName: 5-(Furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide. Canonical SMILES: O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3. Product ID: ACM909089130. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Wnt Agonist II, SKL2001 | The Wnt Agonist II, SKL2001 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide) | A cell-permeable imidazolyl-isoxazolamide that upregulates b-catenin-regulated transcription (CRT; 10-40uM) by disrupting beta-catenin and Axin interaction, thereby preventing b-catenin phosphorylation (Ser33 / Ser37 / Thr41 / Ser45) and proteasomal degradation, without affecting the activities of GSK-3alpha/beta or 18 other kinases (<8.5% inhibition by 10uM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40uM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| SKL 2001 | SKL 2001 is a Wnt/β-catenin signaling pathway agonist that modulates the differentiation of mesenchumal stem cells. It upregulates the β-catenin responsive transcription via increasing the intracellular β-catenin protein level, and inhibits the phosphorylation of β-catenin at residues Ser33/37/Thr41 and Ser45. Synonyms: SKL-2001; SKL 2001; SKL2001; Wnt Agonist II; 5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide. Grades: 99%. CAS No. 909089-13-0. Molecular formula: C14H14N4O3. Mole weight: 286.29. |  |
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