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| Product | Description | |
|---|---|---|
| (E)-SIS3 | An E enantiomer of Smad3 Inhibitor SIS3, an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. SIS3 plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. SIS3 is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts. Synonyms: SIS3; Smad3 inhibitor SIS3; (E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one. Grade: 98%. CAS No. 521985-36-4. Molecular formula: C28H27N3O3. Mole weight: 453.53. |  |
| SIS3 | (E)-SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 ?M for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-?1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 521984-48-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13013. |  |
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