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| Product | Description | |
|---|---|---|
| SMI-4a | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SMI-4a | Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth. Group: Biochemicals. Grades: Highly Purified. CAS No. 327033-36-3. Pack Sizes: 5mg. Molecular Formula: C11H6F3NO2S, Method for Determining. US Biological Life Sciences. |  Worldwide |
| SMI-4a | SMI-4a, also called as TCS-PIM-1-4a, a thiazolidinedione compound, is a potent, selective ATP-competitive inhibitor against Pim protein kinase (IC50 = 24 nM against Pim-1 and 100 nM against Pim-2) with little or no activity against a panel of 58 other kin. Synonyms: SMI-4a; SMI 4a; SMI4a; (5E)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dioneTCS-PIM-1-4aMS-1740; MS 1740; MS1740327033-36-35-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione. CAS No. 327033-36-3. Molecular formula: C11H6F3NO2S. Mole weight: 273.20. |  |
| SMI-4a (5E/Z) -[[3- (Trifluoromethyl) phenyl]methylene]-2, 4-thiazolidinedione) | A selective, ATP-competitive inhibitor Pim-1 (IC50=21nm) and Pim-2 (IC50=100nm) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 327033-36-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (Z)-SMI-4a | (Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. Synonyms: SMI-4a; SMI4a; SMI 4a; TCS PIM-1 4a. CAS No. 438190-29-5. Molecular formula: C11H6F3NO2S. Mole weight: 273.229. | |
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