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Somatostatin-28 is an exceptionally significant neuropeptide hormone extensively employed in the compound field, acting as a superbly adept endogenous modulator of neurotransmitters and hormones. Synonyms: Prosomatostatin; 73032-94-7; Somatostatin 28; Somatostatin-28 (sheep) 28; UNII-14EBZ2F8O6; 14EBZ2F8O6; SRIF-28; SOMATOSTATIN 28, CYCLIC; Somatostatin 28, >=97% (HPLC); LS-15547; LS-145641; FT-0689038. Grades: ≥95%. CAS No. 75037-27-3. Molecular formula: C137H207N41O39S3. Mole weight: 3148.6.
Somatostatin-28 (1-14)
Somatostatin-28 (1-14) has been used to produce antibodies selective for somatostatin-28 that do not bind to the C-terminal fragment somatostatin-14. Synonyms: H-SER-ALA-ASN-SER-ASN-PRO-ALA-MET-ALA-PRO-ARG-GLU-ARG-LYS-OH. CAS No. 79243-10-0. Molecular formula: C61H105N23O21S. Mole weight: 1528.71.
Somatostatin-28 (sheep)
Somatostatin-28 (sheep) is derived from posttranslational cleavage of prosomatostatin, which in turn is derived from a larger precursor, preprosomatostatin. S-28 is an octacosapeptide first isolated from the duodenum of pigs. Unlike S-14, S-28 increases amylase secretion, cellular cyclic GMP and Ca2+ outfluxes in the guinea pig pancreatic acini. Synonyms: H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bridge: Cys17-Cys28); Somatostatin 1-28; L-seryl-L-alanyl-L-asparagyl-L-seryl-L-asparagyl-L-prolyl-L-alanyl-L-methionyl-L-alanyl-L-prolyl-L-arginyl-L-alpha-glutamyl-L-arginyl-L-lysyl-L-alanyl-glycyl-L-cysteinyl-L-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine (17->28)-disulfide; 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontane, cyclic peptide deriv.; Cyclic somatostatin-28; Human somatostatin-28; Somatostatin-28 (human); Somatostatin-28 (pig); Somatostatin-28 (rat); Somatostatin-28 (sheep reduced), cyclic (17?28)-disulfide. Grades: ≥95% by HPLC. CAS No. 73032-94-7. Molecular formula: C137H207N41O39S3. Mole weight: 3148.56.
Cortistatin-29 (rat)
Cortistatin-29 is a neuropeptide that has structurally similarity to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Synonyms: Pyr-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bridge: Cys17-Cys28); 5-oxo-L-prolyl-L-α-glutamyl-L-arginyl-L-prolyl-L-prolyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-prolyl-L-histidyl-L-arginyl-L-α-aspartyl-L-lysyl-L-lysyl-L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-L-lysine, cyclic (17?28)-disulfide; L-pyroglutamyl-L-alpha-glutamyl-L-arginyl-L-prolyl-L-prolyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-prolyl-L-histidyl-L-arginyl-L-alpha-aspartyl-L-lysyl-L-lysyl-L-prolyl-D-cysteinyl-D-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-D-phenylalanyl-D-seryl-L-seryl-L-cysteinyl-L-lysine (17->28)-disulfide. Grades: ≥95%. CAS No. 1815618-17-7. Molecular formula: C161H240N46O41S2. Mole weight: 3540.05.
(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide, a synthetic somatostatin analogue, is selective for human somatostatin receptor subtype 5 (hsst5) and has similar binding affinity to somatostatin-28, with Kd±SEM values of 1200, 23.5±3.92, 11.05±1.03, >1000 and 0.61±0.36 nM for hsst1, hsst2, hsst3, hsst4 and hsst5, respectively. Synonyms: (N-Me-D-Trp4,Thr8)-Octreotide amide; H-D-Phe-Cys-Phe-N-Me-D-Trp-Lys-Thr-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7); D-phenylalanyl-L-cysteinyl-L-phenylalanyl-N-methyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninamide (2->7)-disulfide. Grades: ≥95% by HPLC. CAS No. 340821-13-8. Molecular formula: C50H67N11O10S2. Mole weight: 1046.26.
Somatostatin (Sheep)
It is a growth hormone-release inhibiting factor used in the treatment of severe, acute hemorrhages of gastroduodenal ulcers. It's an experimental diabetes drug. Uses: Growth hormone-release inhibiting factor; treatment of severe, acute hemorrhage of gastroduodenal ulcers; experimental antidiabetic. Synonyms: SRIF-14; Somatostatin-14; H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bridge: Cys3-Cys14); Cyclic somatostatin; 15-28-Somatostatin-28 (sheep); 15:PN:WO2007081792 SEQID:30 claimed protein. Grades: >98%. CAS No. 38916-34-6. Molecular formula: C76H104N18O19S2. Mole weight: 1637.88.
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