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| Product | Description | |
|---|---|---|
| Sonic Hedgehog from mouse | recombinant, expressed in E. coli, ?97% (SDS-PAGE), ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Sonic Hedgehog Peptide from mouse | ?97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Sonic Hedgehog antibody, Mouse monoclonal | clone SH154, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Sonic Hedgehog peptide (C-terminal) antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Sonic Hedgehog peptide (N-terminal) antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Sonic Hedgehog (N-terminal) antibody produced in rat | clone 171018, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Sonic Hedgehog Peptide (C-terminal) antibody produced in rat | clone 55626, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Sonic Hedgehog peptide (N-terminal) antibody produced in rat | clone 171001, purified immunoglobulin, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| 3-Keto-N-aminoethyl-N-aminocaproyldi hydrocinnamoyl Cyclopamine (KAAD-Cyclopamine) | Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells. Group: Biochemicals. Alternative Names: KAAD-Cyclopamine. Grades: Highly Purified. CAS No. 306387-90-6. Pack Sizes: 250ug. US Biological Life Sciences. |  Worldwide |
| AY 9944 | Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol ?7-reductase and ?8,7-sterol isomerase. A sonic hedgehog inhibitor. Group: Biochemicals. Alternative Names: trans-N1, N4-Bis [ (2-chlorophenyl) methyl ] -1, 4-cyclohexane dimethanamine Hydrochloride; N, N'-Bis (o-chlorobenzyl)-trans-1, 4-cyclohexanebis (methylamine) Dihydrochloride. Grades: Highly Purified. CAS No. 366-93-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AY 9944 dihydrochloride | AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It may induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts. It is also a potent inhibitor of cholesterol biosynthesis and esterification, and shows teratogenic properties. It inhibits Δ7-dehydrocholesterol reductase and cholesterol esterificatio, thus reduces cholesterol biosynthesis. It blocks the cellular response to Hh proteins. It is important in Sonic Hedgehog signaling and teratogenicity studies. Synonyms: AY-9944; AY 9944; AY9944; trans-N1,N4-Bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine Hydrochloride; N,N'-Bis(o-chlorobenzyl)-trans-1,4-cyclohexanebis(methylamine) Dihydrochloride; trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 366-93-8. Molecular formula: C22H30Cl4N2. Mole weight: 464.30. |  |
| BMS-833923 | BMS-833923 is an orally bioavailable small-molecule Smo (Smoothened) inhibitor with potential antineoplastic activity. It inhibits the sonic hedgehog (shh) pathway protein Smo, which may result in suppression of shh signaling pathway. Synonyms: BMS 833923; XL139; N-[2-methyl-5-(methylaminomethyl)phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide. Grades: >98%. CAS No. 1059734-66-5. Molecular formula: C30H27N5O. Mole weight: 473.57. | |
| DAPT | Cell permeable gamma-secretase inhibitor (IC50 = 115nM for total beta-amyloid, IC50 = 200nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer. Group: Biochemicals. Alternative Names: (S)-Tert-butyl 2- ( (S) -2- (2- (3, 5-difluorophenyl) acetamido) propanamido) -2-phenylacetate; N-S-phenylglycine tert.butyl ester; GSI-IX; Secretase, gamma Inhibitor IX. Grades: Highly Purified. CAS No. 208255-80-5. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??F?N?O?. US Biological Life Sciences. | Worldwide |
| Despiro-cyclopamine (Despiro-11-Deoxyjervine) | An analogue of Cyclopamine, a sonic hedgehog inhibitor. Group: Biochemicals. Alternative Names: Despiro-11-Deoxyjervine. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| HPI 1 | HPI 1 is a hedgehog (Hh) signaling inhibitor that blocks Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 = 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation) with no effect on Wnt signaling. HPI 1 also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5 μM), and prevents the proliferation of cerebellar granule neuron precursors expressing SmoM2. Synonyms: HPI 1; HPI1; HPI-1; 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester. Grades: ≥95% by HPLC. CAS No. 599150-20-6. Molecular formula: C27H29NO6. Mole weight: 463.52. | |
| HPI 1 (1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester) | Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6um for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation in SmoM2-LIGHT cells (IC50 = 2.5um); inhibits the proliferation of cerebellar granule neuron precursors expressing SmoM2. Does not inhibit Wnt signaling. Group: Biochemicals. Grades: Highly Purified. CAS No. 599150-20-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Jervine | Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from the Veratrum plant species. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Uses: Antibacterial. Synonyms: Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-; (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-Hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethylspiro[9H-benzo[a]fluorene-9, 2'(3'H)-furo[3, 2-b]pyridin]-11(1H)-one; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-; Jervin; NSC 23898; NSC 7520; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, [3S-(3α, 6aα, 6bβ, 9α(3'S*, 3'aR*, 6'R*, 7'aS*), 11aβ, 11bα)]-. Grades: >98%. CAS No. 469-59-0. Molecular formula: C27H39NO3. Mole weight: 425.60. | |
| Jervine ((3ß,23ß)-17,23-Epoxy-3-hydroxyveratraman-11-one) | Has antibacterial properties. Jervine demonstrates teratogenic properties. It is the starting material for C-nor-D-homosteroids. Jervine induces holoprosencephaly and blocks endogenous Sonic hedgehog signaling. Group: Biochemicals. Alternative Names: (3ß,23ß)-17,23-Epoxy-3-hydroxyveratraman-11-one. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| JW 67, Wnt pathway Inhibitor (Induces Degradation of Active B-catenin, Trispiro[3H-indole-3, 2'-[1, 3]dioxane--2'', 3'''-[3H]indole]-2, 2'''(1H, 1'''H)-dione) | Inhibitor of canonical Wnt pathway signaling (IC50 = 1.17um); targets the beta-catenin destruction complex (GSK-3beta/AXIN/APC) to induce beta-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-kappaB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8um). Group: Biochemicals. Grades: Highly Purified. CAS No. 442644-28-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Octyl Maleimide | A sonic hedgehog inhibitor. Also a possible inhibitor of prostaglandin endoperodixide synthases. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Resveratrol | Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 (COX-1). Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 (sirtuin 1) activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Group: Biochemicals. Alternative Names: 3,4,5-Trihydroxy-trans-stilbene; 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol. Grades: Highly Purified. CAS No. 501-36-0. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C14H12O3, Molecular Weight: 228.24. US Biological Life Sciences. | Worldwide |
| Robotnikinin (N-2-acetamide) | Sonic hedgehog (Shh) signaling small molecule modulator. Inhibits the Shh pathway in human cell lines upstream of Smo. Targets the Shh N-terminal protein. Group: Biochemicals. Alternative Names: N--2-acetamide. Grades: Highly Purified. CAS No. 1132653-79-2. Pack Sizes: 1mg. Molecular Formula: C25H27ClN2O4. US Biological Life Sciences. | Worldwide |
| RUSKI-201 dihydrochloride | RUSKI-201 dihydrochloride is a sonic hedgehog acyltransferase (HHAT) inhibitor (IC50 = 0.20 μM) devoid of off-target cytotoxicity, and quantitative whole-proteome palmitoylation profiling with a bioorthogonal alkyne-palmitate reporter. Synonyms: RUSKI-201 dihydrochloride; RUSKI 201 dihydrochloride; RUSKI201 dihydrochloride; 2-(2-methylbutylamino)-1-(4-(6-methylpyridin-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone dihydrochloride. Grades: 98%. Molecular formula: C20H27N3OS.2HCl. Mole weight: 430.43. | |
| SAG Analog | Cell permeable low toxicity Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Potent activator of VEGF expression in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 1401532-78-2. Pack Sizes: 1mg. Molecular Formula: C28H27Cl2N3OS (trans-isomer). US Biological Life Sciences. | Worldwide |
| SAG Analog (cis-isomer) (Compound 10b, 3, 4-Dichloro-N- (cis-4- (methylamino) cyclohexyl) -N- (3-pyridin-4-ylbenzyl) benzo[b]thiophene-2-carboxamide) | A cell-permeable, highly active, Sonic hedgehog (Shh) signaling agonist. Smoothened (Smo) agonist. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| SAG Analog (highly active) (Compound 10b, 3, 4-Dichloro-N- (cis-4- (methylamino) cyclohexyl) -N- (3-pyridin-4-ylbenzyl) benzo[b]thiophene-2-carboxamide) | Cell permeable highly active Sonic hedgehog (Shh) agonist. Group: Biochemicals. Alternative Names: Compound 10b, 3, 4-Dichloro-N- (cis-4- (methylamino) cyclohexyl) -N- (3-pyridin-4-ylbenzyl) benzo[b]thiophene-2-carboxamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SAG Analog (trans-isomer) (Compound 10c, 3, 4-Dichloro-N- (trans-4- (methylamino) cyclohexyl) -N- (3-pyridin-4-ylbenzyl) benzo[b]thiophene-2-carboxamide) | A cell-permeable, low toxicity, Sonic hedgehog (Shh) signaling agonist. Smoothened (Smo) agonist. Also acts as a potent activator of VEGF expression in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug , 1mg. US Biological Life Sciences. | Worldwide |
| SAG Dihydrochloride (Water Soluble) (N-Methyl-N?- (3-pyridinylbenzyl) -N?- (3-chlorobenzo [b]thiophene-2-carbonyl) -1, 4-diaminocyclohexane. 2HCl) | Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 364590-63-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| SANT-1 (N-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine) | A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cell. Group: Biochemicals. Alternative Names: N-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SANT-2 | SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling and an antagonist of smoothened receptor activity (KD = 12 nM). SANT-2 exhibits smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki = 7.8 nM and 8.4 nM, respectively). Synonyms: SANT-2; SANT 2; SANT2; N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide. Grades: ≥98% by HPLC. CAS No. 329196-48-7. Molecular formula: C26H26ClN3O4. Mole weight: 479.96. | |
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