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| Product | Description | |
|---|---|---|
| Sonidegib | Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC 50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Erismodegib; LDE225; NVP-LDE225. CAS No. 956697-53-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16582A. |  |
| Sonidegib | Sonidegib is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. It was approved by the FDA for treating basal-cell carcinoma in July 2015. Synonyms: Erismodegib; LDE225; NVP-LDE225; Odomzo; N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide. Grades: >98%. CAS No. 956697-53-3. Molecular formula: C26H26F3N3O3. Mole weight: 485.507. |  |
| LDE-225 Diphosphate | LDE225 Diphosphate (NVP-LDE225; Erismodegib) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. Synonyms: LDE 225 Diphosphate; LDE225 Diphosphate; Sonidegib phosphate; Erismodegib Diphosphate. CAS No. 1218778-77-8. Molecular formula: C26H32F3N3O11P2. Mole weight: 681.49. | |
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