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| Product | Description | |
|---|---|---|
| Sorafenib tosylate | Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Synonyms: Sorafenib p-toluenesulfonate; BAY 43-9006 Mono-p-tosylate; BAY 54-9085; Nexavar(R); 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate); 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-, mono(4-methylbenzenesulfonate); Bay 43-9006. Grade: ≥ 95%. CAS No. 475207-59-1. Molecular formula: C28H24ClF3N4O6S. Mole weight: 637.03. |  |
| Sorafenib tosylate | Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC 50 s of 6 nM and 20 nM for Raf-1 and B-Raf , respectively. Sorafenib tosylate is a multikinase inhibitor with IC 50 s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2 , VEGFR3 , PDGFRβ , FLT3 and c-Kit , respectively. Sorafenib tosylate induces autophagy and apoptosis. Sorafenib tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bay 43-9006 tosylate. CAS No. 475207-59-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-10201A. |  |
| 4-(4-Aminophenoxy)-2-pyridinecarboxamide | 4-(4-Aminophenoxy)-2-pyridinecarboxamide is one of Sorafenib intermediates. Sorafenib is a polykinase inhibitor of Raf-1, B-Raf and VEGFR-2 and is an anti-tumor drug. Synonyms: 4-(2-Carbamoyl-4-pyridyloxy)aniline; 4-(4-Aminophenoxy)picolinamide; 4-(4-amino-phenoxy)-pyridine-2-carboxylic acid amide; 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-; Sorafenib tosylate Impurity 8; 4-(2-carbamoyl-pyridin-4-yloxy)aniline. Grade: 95%. CAS No. 284462-80-2. Molecular formula: C12H11N3O2. Mole weight: 229.23. | |
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