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| Product | Description | |
|---|---|---|
| SPD304 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| SPD304 | SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC 50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 869998-49-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111255. |  |
| SPD304 dihydrochloride | SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC 50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1049741-03-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111255A. | |
| SPD 304 | SPD 304 a cell-permeable inhibitor of tumor necrosis factor-α (TNFα, IC50 = 22 μM), which is a modulator of inflammation conditions such as rheumatoid arthritis, toxic shock, and sepsis. SPD 304 binids to TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. It inhibits TNF-α-induced IkB-α depletion in HeLa cells (IC50 = 4.6 μM). Uses: Anti-inflammatory agent. Synonyms: SPD-304, SPD 304, SPD304. 6, 7-dimethyl-3- [ [methyl- [2- [methyl- [ [1- [3- (trifluoromethyl) phenyl] indol-3-yl] methyl] amino] ethyl] amino] methyl] chromen-4-one; CAY10500. Grades: 99%. CAS No. 869998-49-2. Molecular formula: C32H32F3N3O2.2HCl. Mole weight: 620.53. |  |
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