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Sphinganine. Group: Biochemicals. Alternative Names: C18-Dihydrosphingosine; (2S,3R)-2-amino-1,3-octadecanediol. Grades: Highly Purified. CAS No. 764-22-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C18H39NO2. US Biological Life Sciences.
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Sphinganine 1-phosphate
Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-erythro-Dihydrosphingosine 1-phosphate. CAS No. 19794-97-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113116.
sphinganine-1-phosphate aldolase
A pyridoxal-phosphate protein. Group: Enzymes. Synonyms: dihydrosphingosine 1-phosphate aldolase; sphinganine-1-phosphate alkanal-lyase; sphinganine-1-phosphate lyase; sphinganine-1-phosphate palmitaldehyde-lyase. Enzyme Commission Number: EC 4.1.2.27. CAS No. 39391-27-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4866; sphinganine-1-phosphate aldolase; EC 4.1.2.27; 39391-27-0; dihydrosphingosine 1-phosphate aldolase; sphinganine-1-phosphate alkanal-lyase; sphinganine-1-phosphate lyase; sphinganine-1-phosphate palmitaldehyde-lyase. Cat No: EXWM-4866.
Sphinganine-1-phosphate (d18:0)
Sphinganine-1-phosphate is an antagonist of the sphingosine-1-phosphate (S1P1/EDG-1) receptor with Ki value of 15 nM. It is a lipid mediator particularly for HDL. Synonyms: D-erythro-sphinganine-1-phosphate; C18-dihydro Sphingosine-1-phosphate; Dihydro-D-erythro-Sphingosine-1-phosphate; D-erythro-Dihydro-D-sphingosine-1-phosphate; [R-(R*,S*)]-2-Amino-1,3-octadecanediol 1-(Dihydrogen Phosphate); (2S,3R)-Sphinganine 1-Phosphate; C18-Dihydrosphingosine 1-Phosphate; Dihydrosphingosine-1-phosphate; (2S,3R)-2-Amino-1,3-octadecanediol 1-(Dihydrogen Phosphate). Grades: ≥95%. CAS No. 19794-97-9. Molecular formula: C18H40NO5P. Mole weight: 381.49.
15-Methylhexadeca Sphinganine
The major sphinganine from the ceramides phospholipids of Bacteroides melaninogenicus as arachidonate cascade inhibitor and blood platelet aggregation inhibitor. Group: Biochemicals. Alternative Names: [R-(R*,S*)]-2-Amino-15-methyl-1,3-hexadecanediol; D-erythro- 2-Amino-15-methyl-1,3-hexadecanediol; D-erythro-C17-iso-Sphinganine. Grades: Highly Purified. CAS No. 26048-10-2. Pack Sizes: 1mg. US Biological Life Sciences.
C18 Dihydroceramide (N-Stearoylsphinganine, Octadecanoyl sphinganine) . Group: Biochemicals. Alternative Names: N-Stearoylsphinganine; Octadecanoyl sphinganine. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
D-erythro-Dihydro-D-sphingosine (Sphinganine)
Biosynthetic precursor of sphingosine. Inhibits protein kinase C. Group: Biochemicals. Alternative Names: Sphinganine. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Sphinganine derivative. Group: Biochemicals. Grades: Highly Purified. CAS No. 750560-88-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
dihydroceramide fatty acyl 2-hydroxylase
The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Enzyme Commission Number: EC 1.14.18.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0969; dihydroceramide fatty acyl 2-hydroxylase; EC 1.14.18.7; FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Cat No: EXWM-0969.
L-threo-Dihydrosphingosine
L-threo-Dihydrosphingosine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-threo-Sphinganine. Appearance: Solid. CAS No. 15639-50-6. Molecular formula: C18H39NO2. Mole weight: 301. Purity: 0.98. Product ID: ACM15639506. Alfa Chemistry ISO 9001:2015 Certified. Categories: SAFINGOL.
Safingol
Safingol is a lyso-sphingolipid protein kinase C (PKC) inhibitor. It binds to and inhibits the regulatory phorbol-binding domain of PKC. It has the potential for the treatment of solid tumors. Synonyms: L-threo-Dihydrosphingosine; L-threo-Sphinganine; L-threo-2-Amino-1,3-octadecanediol; (2S,3S)-2-aminooctadecane-1,3-diol. Grades: ≥98%. CAS No. 15639-50-6. Molecular formula: C18H39NO2. Mole weight: 301.51.
sphingolipid 4-desaturase
The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide. Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain and requires an external cytochrome b5. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation. Group: Enzymes. Synonyms: dehydroceramide desaturase. Enzyme Commission Number: EC 1.14.19.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0979; sphingolipid 4-desaturase; EC 1.14.19.17; dehydroceramide desaturase. Cat No: EXWM-0979.
sphingolipid 8-(E/Z)-desaturase
The enzymes from higher plants convert sphinganine, 4E-sphing-4-enine and phytosphinganine into E/Z-mixtures of Δ8-desaturated products displaying different proportions of geometrical isomers depending on plant species. The nature of the actual desaturase substrate has not yet been studied experimentally. The enzymes contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. The homologous enzymes from some yeasts and diatoms, EC 1.14.19.18, sphingolipid 8-(E)-desaturase, act on sphing-4-enine ceramides and produce only the trans isomer. Group: Enzymes. Synonyms: 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0992; sphingolipid 8-(E/Z)-desaturase; EC 1.14.19.29; 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Cat No: EXWM-0992.
sphingolipid C4-monooxygenase
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase. Group: Enzymes. Synonyms: sphinganine C4-monooxygenase; sphingolipid C4-hydroxylase; SUR2 (gene name); SBH1 (gene name); SBH2 (gene name); DEGS2 (gene name). Enzyme Commission Number: EC 1.14.18.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0967; sphingolipid C4-monooxygenase; EC 1.14.18.5; sphinganine C4-monooxygenase; sphingolipid C4-hydroxylase; SUR2 (gene name); SBH1 (gene name); SBH2 (gene name); DEGS2 (gene name). Cat No: EXWM-0967.
sphingosine kinase
The enzyme is involved in the production of sphingolipid metabolites. It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo-dihydrosphingosine. The exact substrate range depends on the species. Group: Enzymes. Synonyms: SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase. Enzyme Commission Number: EC 2.7.1.91. CAS No. 50864-48-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3121; sphingosine kinase; EC 2.7.1.91; 50864-48-7; SPHK1 (gene name); SPHK2 (gene name); dihydrosphingosine kinase; dihydrosphingosine kinase (phosphorylating); sphingosine kinase (phosphorylating); sphingoid base kinase; sphinganine kinase; ATP:sphinganine 1-phosphotransferase. Cat No: EXWM-3121.
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