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| Product | Description | |
|---|---|---|
| Splitomicin | Splitomicin. Group: Biochemicals. Grades: Purified. CAS No. 5690-3-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Splitomicin | Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. Synonyms: Splitomycin; 2-Hydroxy-1-Naphthalenepropionic Acid δ-Lactone; 2-Hydroxy-1-Naphthalenepropanoic Acid δ-Lactone; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1H-benzo[f]chromen-3(2H)-one; 1H,2H,3H-Naphtho[2,1-b]pyran-3-one; 1,2-Dihydro-3H-benzo[f]chromen-3-one. Grades: ≥98%. CAS No. 5690-3-9. Molecular formula: C13H10O2. Mole weight: 198.22. |  |
| Splitomicin | Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD + -dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC 50 of 60 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Splitomycin. CAS No. 5690-3-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100585. |  |
| Splitomicin (Splitomycin) | Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50 = 60uM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering ot blocking access to the acetylated histone binding pocket. Group: Biochemicals. Grades: Highly Purified. CAS No. 5690-3-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Splitomicin (Splitomycin, 1,2-Dihydro-3H-naphthopyran-3-one, 1-Naphthalen propanoic acid) | Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells. Group: Biochemicals. Alternative Names: Splitomycin, 1,2-Dihydro-3H-naphthopyran-3-one, 1-Naphthalen propanoic acid. Grades: Highly Purified. CAS No. 5690-3-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C13H10O2. US Biological Life Sciences. | Worldwide |
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