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| Product | Description | |
|---|---|---|
| Splitomicin | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Splitomicin | Splitomicin. Group: Biochemicals. Grades: Purified. CAS No. 5690-3-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Splitomicin | Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD + -dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC 50 of 60 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Splitomycin. CAS No. 5690-3-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100585. |  |
| Splitomicin - CAS 5690-03-9 | A cell-permeable lactone derived from ?-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC?? = 60 μM). Group: Fluorescence/luminescence spectroscopy. | |
| Splitomicin (Splitomycin) | Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50 = 60uM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering ot blocking access to the acetylated histone binding pocket. Group: Biochemicals. Grades: Highly Purified. CAS No. 5690-3-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Splitomicin (Splitomycin, 1,2-Dihydro-3H-naphthopyran-3-one, 1-Naphthalen propanoic acid) | Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells. Group: Biochemicals. Alternative Names: Splitomycin, 1,2-Dihydro-3H-naphthopyran-3-one, 1-Naphthalen propanoic acid. Grades: Highly Purified. CAS No. 5690-3-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C13H10O2. US Biological Life Sciences. | Worldwide |
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