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Product | Description | |
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Splitomicin Quick inquiry Where to buy Suppliers range | Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. Synonyms: Splitomycin; 2-Hydroxy-1-Naphthalenepropionic Acid δ-Lactone; 2-Hydroxy-1-Naphthalenepropanoic Acid δ-Lactone; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1H-benzo[f]chromen-3(2H)-one; 1H,2H,3H-Naphtho[2,1-b]pyran-3-one; 1,2-Dihydro-3H-benzo[f]chromen-3-one. Grades: ≥98%. CAS No. 5690-3-9. Molecular formula: C13H10O2. Mole weight: 198.22. | |
Splitomicin Quick inquiry Where to buy Suppliers range | Splitomicin. Group: Biochemicals. Grades: Purified. CAS No. 5690-3-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
Splitomicin Quick inquiry Where to buy Suppliers range | ≥98% (HPLC), powder. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 5690-3-9. Pack Sizes: 5MG. Mole weight: 198.22. Catalog: AP5690039-A. Assay: ≥98% (HPLC). | |
Splitomicin (Splitomycin) Quick inquiry Where to buy Suppliers range | Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50 = 60uM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering ot blocking access to the acetylated histone binding pocket. Group: Biochemicals. Grades: Highly Purified. CAS No. 5690-3-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Splitomicin (Splitomycin, 1,2-Dihydro-3H-naphthopyran-3-one, 1-Naphthalen propanoic acid) Quick inquiry Where to buy Suppliers range | Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells. Group: Biochemicals. Alternative Names: Splitomycin, 1,2-Dihydro-3H-naphthopyran-3-one, 1-Naphthalen propanoic acid. Grades: Highly Purified. CAS No. 5690-3-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C13H10O2. US Biological Life Sciences. | Worldwide |