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| Product | Description | |
|---|---|---|
| Srpin340 | Srpin340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. Srpin340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. Synonyms: SRPIN-340; SRPIN 340. Grades: 99.82%. CAS No. 218156-96-8. Molecular formula: C18H18F3N3O. Mole weight: 349.35. |  |
| SRPIN340 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| SRPIN340 | SRPIN340. Group: Biochemicals. Grades: Purified. CAS No. 218156-96-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340) | A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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