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| Product | Description | |
|---|---|---|
| SSR128129E | SSR128129E is an orally available and allosteric FGFR inhibitor with an IC 50 of 1.9 μM for FGFR1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SSR. CAS No. 848318-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15599. |  |
| SSR128129E | SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment. Synonyms: SSR128129E; SSR 128129E; SSR-128129E. Grades: 0.98. CAS No. 848318-25-2. Molecular formula: C18H15N2NaO4. Mole weight: 346.318. |  |
| SSR128129E free acid | SSR128129E free acid is a multi-FGFR blocker with allosteric properties. It inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. Synonyms: SSR free acid. Grades: >98%. CAS No. 848463-13-8. Molecular formula: C18H16N2O4. Mole weight: 324.33. | |
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