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| Product | Description | |
|---|---|---|
| Stenoparib | Stenoparib, also known as E7449 and 2X-121, is an orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: E7449; E 7449; E-7449; 2X-121; 2X 121; 2X121; Stenoparib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1140964-99-3. Molecular formula: C18H15N5O. Mole weight: 317.34. Purity: >98%. IUPACName: 8-(isoindolin-2-ylmethyl)-2H-pyridazino[3,4,5-de]quinazolin-3(9H)-one. Canonical SMILES: O=C1NN=C(N2)C3=C(C=CC=C31)N=C2CN(C4)CC5=C4C=CC=C5. Product ID: ACM1140964993. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Stenoparib | Stenoparib (E7449) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2 , with IC 50 s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32 P-NAD + as substrate. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E7449; 2X-121. CAS No. 1140964-99-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12418. |  |
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