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| Product | Description | |
|---|---|---|
| STM2457 | STM2457 Inhibitor. Uses: Scientific use. Product Category: T9060. CAS No. 2499663-01-1. |  |
| STM2457 | STM2457 is a highly potent and selective first-in-class catalytic inhibitor of METTL3. Treatment of tumours with STM2457 leads to reduced AML growth and an increase in differentiation and apoptosis. These cellular effects are accompanied by selective reduction of m6A levels on known leukaemogenic mRNAs and a decrease in their expression consistent with a translational defect. Pharmacological inhibition of METTL3 in vivo leads to impaired engraftment and prolonged survival in various mouse models of AML, specifically targeting key stem cell subpopulations of AML. Uses: Designed for use in research and industrial production. Additional or Alternative Names: STM2457; STM-2457; STM 2457. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2499663-01-1. Molecular formula: C25H28N6O2. Mole weight: 444.54. Purity: >98%. IUPACName: N-((6-(((cyclohexylmethyl)amino)methyl)imidazo[1,2-a]pyridin-2-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide. Canonical SMILES: C1=CC=CC2=NC(C(=O)NCC3N=C4C=CC(CNCC5CCCCC5)=CN4C=3)=CC(=O)N12. Product ID: ACM2499663011. Alfa Chemistry ISO 9001:2015 Certified. |  |
| STM2457 | STM2457 is a potent and selective METTL3 inhibitor. It is used for the research of acute myeloid leukaemia (AML). Synonyms: STM2457; STM 2457. CAS No. 2499663-01-1. Molecular formula: C25H28N6O2. Mole weight: 444.54. |  |
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