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| Product | Description | |
|---|---|---|
| STX-0119 | STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes and stem cell-associated genes as well as the induction of apoptosis in one stem-like cell line. STX-0119 may serve as a novel therapeutic compound against GBM-SCs even in temozolomide-resistant GBM patients and has the potential for GBM-SC-specific therapeutics in combination with temozolomide plus radiation therapy. Synonyms: STX 0119; STX0119. Grades: 98%. CAS No. 851095-32-4. Molecular formula: C22H14N4O3. Mole weight: 382.38. |  |
| STAT3 Inhibitor XI, STX-0119 (N-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)-2-phenylquinoline-4-carboxamide) | A cell-permeable oxadiazolyl-quinolinecarboxamide that is shown to selectively suppress STAT3, but not STAT1, STAT5a, or STAT5b, DNA binding activity and prevent IL-6-stimulated STAT3 dimerization in HEK293 cells (by 99% at 100uM), as well as inhibit the expression of STAT3 target genes both in cultures in vitro (effective conc. 50uM) and in SCC3-derived tumors in mice in vivo (160mg/kg/day; p.o.). Group: Biochemicals. Grades: Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
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